Evidence map›Paper›PMID 29195841›Full record

ArticleJournal of cardiovascular computed tomography

Incidental pulmonary nodules in emergent coronary CT angiography for suspected acute coronary syndrome: Impact of revised 2017 Fleischner Society Guidelines.

Jan-Erik Scholtz, Michael T Lu, Sandeep Hedgire, Nina M Meyersohn, George R Oliveira, Anand M Prabhakar, Rajiv Gupta, Mannudeep K Kalra, Jo-Anne O Shepard, Udo Hoffmann and 1 more

Abstract readComparative Study
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Lung cancer in the emergency department.Emergency cancer care · 2023
    Review
  9. Observational
  10. Incidental findings on cardiac computed tomography: No new emergencies to declare!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  11. Radiomics Improves Cancer Screening and Early Detection.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Incidental Non-cardiac Findings in Cardiovascular Imaging.Current treatment options in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jan-Erik ScholtzCardiac MR PET CT Program, Department of Radiology (Cardiovascular Imaging) and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114-2750, USA; Department for Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann-Wolfgang-Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany. Electronic address: janerikscholtz@gmail.com.
Michael T LuCardiac MR PET CT Program, Department of Radiology (Cardiovascular Imaging) and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114-2750, USA.
Sandeep HedgireCardiac MR PET CT Program, Department of Radiology (Cardiovascular Imaging) and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114-2750, USA.
Nina M MeyersohnCardiac MR PET CT Program, Department of Radiology (Cardiovascular Imaging) and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114-2750, USA.
George R OliveiraDepartment for Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann-Wolfgang-Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
Anand M PrabhakarDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114-2750, USA.
Rajiv GuptaDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114-2750, USA.
Mannudeep K KalraDepartment for Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann-Wolfgang-Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
Jo-Anne O ShepardDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114-2750, USA.
Udo HoffmannCardiac MR PET CT Program, Department of Radiology (Cardiovascular Imaging) and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114-2750, USA.
Brian B GhoshhajraCardiac MR PET CT Program, Department of Radiology (Cardiovascular Imaging) and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114-2750, USA.

Funding

Cardiovascular Imaging in Ischemic Heart DiseaseK24HL113128 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2012 to 2020
$1.1M
NHLBI NIH HHS K24 HL113128
6 · The paper itself

Abstract

backgroundPulmonary nodules (PN) are frequently detected incidentally during coronary computed tomography angiography (CTA). We evaluated whether the 2017 Fleischner Society guidelines may result in a decrease of follow-up testing of incidental PN as compared to prior guidelines in patients undergoing coronary CTA.

methodsWe conducted a retrospective study of a registry of emergency department patients who underwent coronary CTA for acute coronary syndrome assessment between 2012 and 2017. Based on guidelines, patients <35 years, history of cancer, or prior exams showing stability of PN were excluded. Patients >60 years, history of smoking, irregular/spiculated PN morphology, or PN size >20 mm were classified as high-risk for lung cancer. Radiological findings pertaining to PN were identified (PN size, morphology, quantity) through review of radiology reports. PN follow-up recommendations were established using 2017 Fleischner Society Guidelines and compared with prior guidelines for solid (2005) and subsolid (2013) PN. Data were analyzed with Student's t-test.

resultsThe registry included 2066 patients (female 45.1%, 52.9 ± 11.0 years), of which 578 (28.0%) reported PN. 438 of those (21.2%) were eligible for guideline-based follow-up evaluation. 205 (4 6.8%) were classified as high-risk for lung cancer. 2017 guidelines reduced the number of individuals requiring follow-up by 64.5%, from 264 (12.8%) to 94 patients (4.5%) when compared to prior guidelines (p < 0.001). The minimum number of follow-up chest CTs decreased by 55.8% from 430 to 190 (p < 0.001).

conclusionApplication of the 2017 Fleischner Society Guidelines resulted in a significant decrease of follow-up testing for incidental PN in patients undergoing coronary CTA for suspected acute coronary syndrome.

Indexed as

Emergency Service, HospitalIncidental FindingsAcute Coronary SyndromeAdultComputed Tomography AngiographyCoronary AngiographyFemaleHumansMaleMiddle AgedMultiple Pulmonary NodulesPractice Guidelines as TopicPredictive Value of TestsRegistriesRetrospective StudiesSolitary Pulmonary NoduleAcute coronary syndromeCoronary computed tomography angiographyFleischner Society GuidelinesFollow-up CTIncidental findingsLung noduleManagement of incidental lung nodulesPulmonary nodule

Identifiers

PMID29195841
PMCPMC5903561

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.