Evidence map›Paper›PMID 29195759›Full record

ReviewMetabolism: clinical and experimental2018

Circadian regulation of glucose, lipid, and energy metabolism in humans.

Eleonora Poggiogalle, Humaira Jamshed, Courtney M Peterson

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolism: clinical and experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06887543 (The Impact of Time Restricted Eating on Type 2 Diabetes Study), which is not on this map. Cited by 350 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06887543 naterminatednot on this mapstarted 2025, after this paper: background citation

The Impact of Time Restricted Eating on Type 2 Diabetes Study

TypeinterventionalSponsorRockefeller UniversityRan2025 to 2025Enrolled2ConditionsType 2 DiabetesArmsMeal timing, Time restricted eating, Usual feeding pattern.
3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  3. Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eleonora PoggiogalleDepartment of Experimental Medicine, Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University, Rome, Italy.
Humaira JamshedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Courtney M PetersonDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: cpeterso@uab.edu.

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
UAB Center for Clinical and Translational Science (CCTS)KL2TR001419 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2018
$2.5M
NCATS NIH HHS KL2 TR001419NCATS NIH HHS UL1 TR001417NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms organize metabolism by temporally separating opposing metabolic processes and by anticipating recurring feeding-fasting cycles to increase metabolic efficiency. Although animal studies demonstrate that the circadian system plays a pervasive role in regulating metabolism, it is unclear how, and to what degree, circadian research in rodents translates into humans. Here, we review evidence that the circadian system regulates glucose, lipid, and energy metabolism in humans. Using a range of experimental protocols, studies in humans report circadian rhythms in glucose, insulin, glucose tolerance, lipid levels, energy expenditure, and appetite. Several of these rhythms peak in the biological morning or around noon, implicating earlier in the daytime is optimal for food intake. Importantly, disruptions in these rhythms impair metabolism and influence the pathogenesis of metabolic diseases. We therefore also review evidence that circadian misalignment induced by mistimed light exposure, sleep, or food intake adversely affects metabolic health in humans. These interconnections among the circadian system, metabolism, and behavior underscore the importance of chronobiology for preventing and treating type 2 diabetes, obesity, and hyperlipidemia.

Indexed as

Carbohydrate MetabolismEnergy MetabolismLipid MetabolismAnimalsChronobiology DisordersCircadian RhythmGlucoseHumansMealsSleepGlucoseCircadianCircadian misalignmentDiurnal rhythmMeal timing

Identifiers

PMID29195759
PMCPMC5995632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.