Evidence map›Paper›PMID 29195273›Full record

ArticleJournal of proteome research2018

Proteoform Suite: Software for Constructing, Quantifying, and Visualizing Proteoform Families.

Anthony J Cesnik, Michael R Shortreed, Leah V Schaffer, Rachel A Knoener, Brian L Frey, Mark Scalf, Stefan K Solntsev, Yunxiang Dai, Audrey P Gasch, Lloyd M Smith

Abstract read
In one paragraph

Article in Journal of proteome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Intact Mass Proteomics Using a Proteoform Atlas.Journal of proteome research · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Proteoforms and Proteoform Families: Past, Present, and Future.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Novel Strategies to Address the Challenges in Top-Down Proteomics.Journal of the American Society for Mass Spectrometry · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anthony J CesnikDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.ORCID 0000-0002-5326-7134
Michael R ShortreedDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Leah V SchafferDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.ORCID 0000-0001-6339-9141
Rachel A KnoenerDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Brian L FreyDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.ORCID 0000-0002-0397-7269
Mark ScalfDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Stefan K SolntsevDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Yunxiang DaiDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Audrey P GaschDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Lloyd M SmithDepartment of Chemistry, ‡Laboratory of Genetics, and §Genome Center of Wisconsin, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

Funding

Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Intact Proteoform Identification and QuantificationR01GM114292 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GOULD, MICHAEL N, SMITH, LLOYD M · 2015 to 2018
$1.6M
NIGMS NIH HHS R01 GM114292NIGMS NIH HHS T32 GM008349NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

We present an open-source, interactive program named Proteoform Suite that uses proteoform mass and intensity measurements from complex biological samples to identify and quantify proteoforms. It constructs families of proteoforms derived from the same gene, assesses proteoform function using gene ontology (GO) analysis, and enables visualization of quantified proteoform families and their changes. It is applied here to reveal systemic proteoform variations in the yeast response to salt stress.

Indexed as

SoftwareFungal ProteinsGene OntologyMass SpectrometryProteomicsSaltsStress, PhysiologicalFungal ProteinsSaltsidentificationintact masslysine countmodificationNeuCodeproteoformPTMquantificationvisualization

Identifiers

PMID29195273
PMCPMC5770237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.