ArticleBiomacromolecules2018
Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms.
Article in Biomacromolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Circular-by-Design Zwitterionic Polyglycerol-Polyoxazoline-Lysine Pseudodendrimers as Multifunctional Antibacterial and Anticancer Drug Delivery Platforms.Biomacromolecules · 2026Article
- Impact of protein corona and light modulation on the antibacterial activity of light-activated silver nanoparticles.Journal of materials chemistry. B · 2025Article
- Quantitative Characterization of Localized Hydrophobicity Surrounding Polymer Particle Surfaces for Aqueous Antibacterial Colloids.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Nano-enabled antimicrobial thin films: design and mechanism of action.RSC advances · 2024Review
- Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly.Materials horizons · 2023Article
- Mechanistic insights into nanoparticle surface-bacterial membrane interactions in overcoming antibiotic resistance.Frontiers in microbiology · 2023Review
- Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles.Materials advances · 2022Article
- Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains andRSC advances · 2022Article
- Therapeutic Applications of Self-assembled Indole-3-butanoyl-polyethylenimine Nanostructures.Indian journal of microbiology · 2022Article
- Coordination Properties of the Zinc Domains of BigR4 and SmtB Proteins in Nickel Systems─Designation of Key Donors.Inorganic chemistry · 2022Article
- Poly[2-(dimethylamino)ethyl methacrylate-RSC advances · 2021Article
- Automation and data-driven design of polymer therapeutics.Advanced drug delivery reviews · 2021Review
- Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance.Frontiers in chemistry · 2021Review
- Precision Design of Antimicrobial Surfaces.Frontiers in medical technology · 2021Article
- The Effects of Luminescent CdSe Quantum Dot-Functionalized Antimicrobial Peptides Nanoparticles on Antibacterial Activity and Molecular Mechanism.International journal of nanomedicine · 2021Article
- Nano-vehicles give new lease of life to existing antimicrobials.Emerging topics in life sciences · 2020Review
- Photochemical "In-Air" Combinatorial Discovery of Antimicrobial Co-polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Because of the emergence of antimicrobial resistance to traditional small-molecule drugs, cationic antimicrobial polymers are appealing targets. Mycobacterium tuberculosis is a particular problem, with multi- and total drug resistance spreading and more than a billion latent infections globally. This study reports nanoparticles bearing variable densities of poly(dimethylaminoethyl methacrylate) and the unexpected and distinct mechanisms of action this multivalent presentation imparts against Escherichia coli versus Mycobacterium smegmatis (model of M. tuberculosis), leading to killing or growth inhibition, respectively. A convergent "grafting to" synthetic strategy was used to assemble a 50-member nanoparticle library, and using a high-throughput screen identified that only the smallest (2 nm) particles were stable in both saline and complex cell media. Compared with the linear polymers, the nanoparticles displayed two- and eight-fold enhancements in antimicrobial activity against M. smegmatis and E. coli, respectively. Mechanistic studies demonstrated that the antimicrobial particles were bactericidal against E. coli due to rapid disruption of the cell membranes. Conversely, against M. smegmatis the particles did not lyse the cell membrane but rather had a bacteriostatic effect. These results demonstrate that to develop new polymeric antituberculars the widely assumed, broad spectrum, membrane-disrupting mechanism of polycations must be re-evaluated. It is clear that synthetic nanomaterials can engage in more complex interactions with mycobacteria, which we hypothesize is due to the unique cell envelope at the surface of these bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.