Evidence map›Paper›PMID 29195045›Full record

ArticleJournal of chemical information and modeling2018

Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor.

Khuraijam Dhanachandra Singh, Hamiyet Unal, Russell Desnoyer, Sadashiva S Karnik

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Sartan-induced interstitial lung disease.Respiratory medicine case reports · 2023
    Article
  2. Review
  3. Article
  4. Article
  5. Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Khuraijam Dhanachandra SinghDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, Ohio 44195, United States.
Hamiyet UnalDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, Ohio 44195, United States.
Russell DesnoyerDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, Ohio 44195, United States.
Sadashiva S KarnikDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, Ohio 44195, United States.ORCID 0000-0003-0746-2753
Cleveland Clinic · US

Funding

Molecular Basis of Ang II Receptor FunctionsR01HL057470 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 1997 to 2013
$4.4M
Structure-Guided Studied of GPCRs of RASR01HL132351 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2017 to 2019
$1.6M
Regulation of AT1R-signaling and pathology in vessels through microRNAR01HL115964 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2012 to 2015
$1.5M
Structure-Guided Analysis of Mechanisms of AT1R FunctionsR56HL132351 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2016 to 2016
$548k
NHLBI NIH HHS R01 HL057470NHLBI NIH HHS R01 HL115964NHLBI NIH HHS R01 HL132351NHLBI NIH HHS R56 HL132351
6 · The paper itself

Abstract

Crystal structures of the human angiotensin II type 1 receptor (AT

Indexed as

Drug DesignAngiotensin II Type 1 Receptor BlockersCrystallography, X-RayHumansMolecular Docking SimulationMolecular Dynamics SimulationMutagenesis, Site-DirectedReceptor, Angiotensin, Type 1Spatio-Temporal AnalysisAngiotensin II Type 1 Receptor BlockersReceptor, Angiotensin, Type 1

Identifiers

PMID29195045
PMCPMC6058968
OpenAlexW2772214775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.