Evidence map›Paper›PMID 29194834›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018

Lipid-DNAs as Solubilizers of mTHPC.

Yun Liu, Jan Willem de Vries, Qing Liu, Alwin M Hartman, Gerhard D Wieland, Sebastian Wieczorek, Hans G Börner, Arno Wiehe, Eric Buhler, Marc C A Stuart and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Lipid-DNAs as Solubilizers of mTHPC.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Yun LiuStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747, AG Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-2154-9559
Jan Willem de VriesDepartment of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG Groningen, The Netherlands.
Qing LiuDepartment of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG Groningen, The Netherlands.
Alwin M HartmanStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747, AG Groningen, The Netherlands.
Gerhard D Wielandbiolitec research GmbH, Otto-Schott-Strasse 15, 07745, Jena, Germany.ORCID http://orcid.org/0000-0003-1034-4897
Sebastian WieczorekLaboratory for Organic Synthesis of Functional Systems, Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.
Hans G BörnerLaboratory for Organic Synthesis of Functional Systems, Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.ORCID http://orcid.org/0000-0001-9333-9780
Arno Wiehebiolitec research GmbH, Otto-Schott-Strasse 15, 07745, Jena, Germany.
Eric BuhlerLaboratoire Matière et Systèmes Complexes (MSC) UMR 7057, Université Paris Diderot-Paris 7, Bâtiment Condorcet, 75205, Paris cedex 13, France.ORCID http://orcid.org/0000-0003-3946-1982
Marc C A StuartStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747, AG Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-0667-6338
Wesley R BrowneMolecular Inorganic Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747, AG Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-5063-6961
Andreas HerrmannDepartment of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-8886-0894
Anna K H HirschStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747, AG Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8734-4663
University of Groningen · NLHumboldt-Universität zu Berlin · DESchott (Germany) · DEUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrophobic drug candidates require innovative formulation agents. We designed and synthesized lipid-DNA polymers containing varying numbers of hydrophobic alkyl chains. The hydrophobicity of these amphiphiles is easily tunable by introducing a defined number of alkyl chain-modified nucleotides during standard solid-phase synthesis of DNA using an automated DNA synthesizer. We observed that the resulting self-assembled micelles solubilize the poorly water-soluble drug, meta-tetra-hydroxyphenyl-chlorin (mTHPC) used in photodynamic therapy (PDT) with high loading concentrations and loading capacities. A cell viability study showed that mTHPC-loaded micelles exhibit good biocompatibility without irradiation, and high PDT efficacy upon irradiation. Lipid-DNAs provide a novel class of drug-delivery vehicle, and hybridization of DNA offers a potentially facile route for further functionalization of the drug-delivery system with, for instance, targeting or imaging moieties.

Indexed as

amphiphilesdrug deliverylipid-DNAmicellesphotodynamic therapy

Identifiers

PMID29194834
PMCPMC5814723
OpenAlexW2773568286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.