Evidence map›Paper›PMID 29194766›Full record

ArticleJournal of veterinary internal medicine2018

Absence Seizures as a Feature of Juvenile Myoclonic Epilepsy in Rhodesian Ridgeback Dogs.

F Wielaender, F M K James, M A Cortez, G Kluger, J N Neßler, A Tipold, H Lohi, A Fischer

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Electroencephalography: electrode arrays in dogs.Frontiers in veterinary science · 2024
    Review
  5. Article
  6. Dogs as a Natural Animal Model of Epilepsy.Frontiers in veterinary science · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Behavioral Changes Under Levetiracetam Treatment in Dogs.Frontiers in veterinary science · 2020
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 6 countries.

F WielaenderCentre for Clinical Veterinary Medicine, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-3113-5659
F M K JamesDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.ORCID http://orcid.org/0000-0003-4331-4993
M A CortezDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
G KlugerDepartment of Neuropediatrics, Epilepsy Center, Schoen Klinik, Vogtareuth, Germany.
J N NeßlerDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
A TipoldDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
H LohiDepartment of Veterinary Biosciences and Research Programs Unit, Molecular Neurology, University of Helsinki and Folkhalsan Research Centre, Helsinki, Finland.
A FischerCentre for Clinical Veterinary Medicine, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7094-1947
Centre of Experimental Medicine of the Slovak Academy of Sciences · SKUniversity of Veterinary Medicine Hannover, Foundation · DEParacelsus Medical University · ATUniversity of Guelph · CAUniversity of Helsinki · FIUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoclonic epilepsy in Rhodesian Ridgeback (RR) dogs is characterized by myoclonic seizures occurring mainly during relaxation periods, a juvenile age of onset and generalized tonic-clonic seizures in one-third of patients. An 8-month-old female intact RR was presented for myoclonic seizures and staring episodes that both started at 10 weeks of age. Testing for the DIRAS1 variant indicated a homozygous mutant genotype. Unsedated wireless video-electroencephalography (EEG) identified frequent, bilaterally synchronous, generalized 4 Hz spike-and-wave complexes (SWC) during the staring episodes in addition to the characteristic myoclonic seizures with generalized 4-5 Hz SWC or 4-5 Hz slowing. Photic stimulation did not evoke a photoparoxysmal response. Repeat video-EEG 2 months after initiation of levetiracetam treatment disclosed a >95% decrease in frequency of myoclonic seizures, and absence seizures were no longer evident. Absence seizures represent another seizure type in juvenile myoclonic epilepsy (JME) in RR dogs, which reinforces its parallels to JME in humans.

Indexed as

AnimalsAnticonvulsantsDog DiseasesDogsElectroencephalographyEpilepsies, MyoclonicFemaleGTP PhosphohydrolasesLevetiracetamMutationPhotic StimulationPiracetamSeizuresTumor Suppressor ProteinsAnticonvulsantsGTP PhosphohydrolasesLevetiracetamPiracetamTumor Suppressor ProteinsCanineDIRAS1Electroencephalography (EEG)Wireless video-EEG

Identifiers

PMID29194766
PMCPMC5787207
OpenAlexW2774724580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.