ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018
Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- MSC Origin and Biomechanical Conditioning Determine ECM Maturation in Tissue-Engineered Matrix.Biomedicines · 2026Article
- Tissue maturation and development of mechanical properties in hyaluronic acid bioink-based cartilaginous constructs.Frontiers in bioengineering and biotechnology · 2026Article
- Crosstalk between lymphatic system and synovial inflammatory cells in osteoarthritis: molecular mechanisms and potential cell-based therapies.Journal of translational medicine · 2025Review
- Chondrogenic potential of PMSCs cultured on chondroitin sulfate/gelatin-modified DBM scaffold.BioImpacts : BI · 2025Article
- The Interaction Between Microbiota and Stem Cells on Progression of Osteoarthritis and Engineered Stem Cell for Enhancing Osteoarthritis Treatment.International journal of nanomedicine · 2025Review
- Key Role of STAT3 in Osteoarthritis: From Pathogenic Mechanisms to Targeted Therapy.International journal of nanomedicine · 2025Review
- Electrospun bioactive polymer biomaterials enriched with collagen and platelet-rich plasma as a platform forFrontiers in bioengineering and biotechnology · 2025Article
- Calcium Phosphate-Coated and Strontium-Incorporated Mesoporous Silica Nanoparticles Can Effectively Induce Osteogenic Stem Cell Differentiation.Advanced healthcare materials · 2022Article
- Cartilage repair using stem cells & biomaterials: advancement from bench to bedside.Molecular biology reports · 2020Review
- Transcriptome dynamics of long noncoding RNAs and transcription factors demarcate human neonatal, adult, and human mesenchymal stem cell-derived engineered cartilage.Journal of tissue engineering and regenerative medicine · 2020Article
- There Is No "Stem Cell Mess".Tissue engineering. Part B, Reviews · 2019Review
- Ontogeny informs regeneration: explant models to investigate the role of the extracellular matrix in cartilage tissue assembly and development.Connective tissue researchReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Regenerative medicine and tissue engineering studies are actively developing novel means to repair adult articular cartilage defects using biological approaches. One such approach is the harnessing of adult human therapeutic cells such as those referred to as mesenchymal stem cells. Upon exposure to chondrogenic signals, these cells differentiate and initiate the production of a complex and voluminous cartilaginous matrix that is crucial to both the structure and function of cartilage. Furthermore, this complexity requires the time-sensitive activation of a large number of genes to produce the components of this matrix. The current study analyzed the kinetics of matrix production in an aggregate culture model where adult human mesenchymal stem cells were induced to differentiate as chondrocytes. The results indicate the existence of a biphasic mode of differentiation and maturation during which matrix genes and molecules are differentially activated and secreted. These results have important implications for developing novel approaches for the creation of tissue engineered articular cartilage. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1757-1766, 2018.
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