ArticleSchizophrenia bulletin2018
Deficits in Cortical Suppression During Vocalization are Associated With Structural Abnormalities in the Arcuate Fasciculus in Early Illness Schizophrenia and Clinical High Risk for Psychosis.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Trial
- Corollary Discharge Dysfunction to Inner Speech and its Relationship to Auditory Verbal Hallucinations in Patients with Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Effects of Methylenetetrahydrofolate Reductase Polymorphism on Clinical Features of High-Risk Psychosis Before Schizophrenia.Psychiatry investigation · 2025Article
- Article
- A narrative literature review of white matter microstructure in individuals at clinical high risk for psychosis.Psychoradiology · 2025Review
- Corollary Discharge Dysfunction as a Possible Substrate of Anomalous Self-experiences in Schizophrenia.Schizophrenia bulletin · 2024Article
- Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition.Nature communications · 2023Article
- Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Thalamo-cortical circuits during sensory attenuation in emerging psychosis: a combined magnetoencephalography and dynamic causal modelling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Automatic Schizophrenia Detection Using Multimodality Media via a Text Reading Task.Frontiers in neuroscience · 2022Article
- Disturbances in White Matter Integrity in the Ultra-High-Risk Psychosis State-A Systematic Review.Journal of clinical medicine · 2021Review
- White Matter Microstructural Abnormalities in the Broca's-Wernicke's-Putamen "Hoffman Hallucination Circuit" and Auditory Transcallosal Fibers in First-Episode Psychosis With Auditory Hallucinations.Schizophrenia bulletin · 2021Article
- Abnormal ERPs and Brain Dynamics Mediate Basic Self Disturbance in Schizophrenia: A Review of EEG and MEG Studies.Frontiers in psychiatry · 2021Review
- Investigating cortico-subcortical circuits during auditory sensory attenuation: A combined magnetoencephalographic and dynamic causal modeling study.Human brain mapping · 2020Article
- Motor Impairment and Developmental Psychotic Risk: Connecting the Dots and Narrowing the Pathophysiological Gap.Schizophrenia bulletin · 2019Article
- Prediction of Speech Sounds Is Facilitated by a Functional Fronto-Temporal Network.Frontiers in neural circuits · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Self-generated speech produces a smaller N1 amplitude in the auditory-evoked potential than externally generated speech; this phenomenon is known as N1-suppression. Schizophrenia patients show less N1-suppression than healthy controls. This failure to self-suppress may underlie patients' characteristic tendency to misattribute self-generated thoughts and actions to external sources. While the cause of N1-suppression deficits to speech in schizophrenia remains unclear, structural damage to the arcuate fasciculus is a candidate, due to its ostensible role in transmitting the efference copy of the motor plan to speak. Fifty-one patients with early illness schizophrenia (ESZ), 40 individuals at clinical high-risk for psychosis (CHR), and 59 healthy control (HC) participants underwent an electroencephalogram while they spoke and then listened to a recording of their speech. N1-suppression to the spoken sounds was calculated. Participants also underwent a diffusion-tensor imaging (DTI) scan, from which the arcuate fasciculus and pyramidal tract were extracted with deterministic tractography. ESZ patients exhibited significantly less N1-suppression to self-generated speech than HC participants, with CHR participants exhibiting intermediate levels. ESZ patients also exhibited structural abnormalities in the arcuate fasciculus-specifically, reduced fractional anisotropy and increased radial diffusivity-relative to both HC and CHR. There were no between-group differences in the structural integrity of the pyramidal tract. Finally, level of N1-suppression was linearly related to the structural integrity of the arcuate fasciculus, but not the pyramidal tract, across groups. These results suggest that the self-suppression deficits to willed speech consistently observed in schizophrenia patients may be caused, at least in part, by structural damage to the arcuate fasciculus.
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Registered trials
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