ArticlePLoS computational biology2017
Genetic drift and selection in many-allele range expansions.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Biosurfactants direct the evolutionary dynamics of surface-associated microbial systems.Science advances · 2026Article
- Disentangling the feedback loops driving spatial patterning in microbial communities.NPJ biofilms and microbiomes · 2025Review
- Navigated range expansion promotes migratory culling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Phage predation accelerates the spread of plasmid-encoded antibiotic resistance.Nature communications · 2024Article
- Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations.Nature communications · 2022Article
- The contrasting roles of nitric oxide drive microbial community organization as a function of oxygen presence.Current biology : CB · 2022Article
- Growth instabilities shape morphology and genetic diversity of microbial colonies.Physical biology · 2022Article
- Spatial organization in microbial range expansion emerges from trophic dependencies and successful lineages.Communications biology · 2020Article
- Dynamic motility selection drives population segregation in a bacterial swarm.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Increasing growth rate slows adaptation when genotypes compete for diffusing resources.PLoS computational biology · 2020Article
- Article
- The Complexities of Metastasis.Cancers · 2019Review
- Article
- Physical interactions reduce the power of natural selection in growing yeast colonies.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We experimentally and numerically investigate the evolutionary dynamics of four competing strains of E. coli with differing expansion velocities in radially expanding colonies. We compare experimental measurements of the average fraction, correlation functions between strains, and the relative rates of genetic domain wall annihilations and coalescences to simulations modeling the population as a one-dimensional ring of annihilating and coalescing random walkers with deterministic biases due to selection. The simulations reveal that the evolutionary dynamics can be collapsed onto master curves governed by three essential parameters: (1) an expansion length beyond which selection dominates over genetic drift; (2) a characteristic angular correlation describing the size of genetic domains; and (3) a dimensionless constant quantifying the interplay between a colony's curvature at the frontier and its selection length scale. We measure these parameters with a new technique that precisely measures small selective differences between spatially competing strains and show that our simulations accurately predict the dynamics without additional fitting. Our results suggest that the random walk model can act as a useful predictive tool for describing the evolutionary dynamics of range expansions composed of an arbitrary number of genotypes with different fitnesses.
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