Evidence map›Paper›PMID 29194430›Full record

ArticleViruses2017

Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response.

Jun Chen, Sisi Xia, Xiangmin Yang, Huizi Chen, Fanni Li, Fenyong Liu, Zhinan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. BLV-miR-B1-5p PromotesAnimals : an open access journal from MDPI · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer.International journal of biological sciences · 2021
    Review
  14. Article
  15. Review
  16. Potential of Immune-Related Therapy in COVID-19.Frontiers in pharmacology · 2020
    Review
  17. Frontiers in immunology · 2020
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jun ChenNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. cjun@whu.edu.cn.
Sisi XiaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. xiasisi@whu.edu.cn.
Xiangmin YangNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. yxiangmind@163.com.
Huizi ChenDepartment of Immunology, Zunyi Medical College, Guizhou 563000, China. chen_huizi@126.com.
Fanni LiNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. fannycpu@163.com.
Fenyong LiuDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA. liu_fy@berkeley.edu.
Zhinan ChenNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. zhinanchen@fmmu.edu.cn.
Air Force Medical University · CNUniversity of California, Berkeley · USWuhan University · CNZunyi Medical University · CN

Funding

Persistent infection of human cytomegalovirus in oral mucosaR01DE025462 · NIDCR · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIU, FENYONG · 2015 to 2019
$2.3M
Human cytomegalovirus chromatin modifications in oral infectionR01DE023935 · NIDCR · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIU, FENYONG · 2013 to 2017
$2.3M
NIDCR NIH HHS R01 DE023935NIDCR NIH HHS R01 DE025462
6 · The paper itself

Abstract

Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection. However, the involvement of type-I transmembrane glycoprotein CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) in the antiviral response to HCMV infection is still unknown. Here, we demonstrated the specific knockdown of CD147 significantly decreased HCMV-induced activation of NF-κB and Interferon-beta (IFN-β), which contribute to the cellular antiviral responses. Next, we confirmed that HCMV-encoded miR-US25-1-5p could target the 3' UTR (Untranslated Region) of CD147 mRNA, and thus facilitate HCMV lytic propagation at a low multiplicity of infection (MOI). The expression and secretion of Cyclophilin A (sCyPA), as a ligand for CD147 and a proinflammatory cytokine, were up-regulated in response to HCMV stimuli. Finally, we confirmed that CD147 mediated HCMV-triggered antiviral signaling via the sCyPA-CD147-ERK (extracellular regulated protein kinases)/NF-κB axis signaling pathway. These findings reveal an important HCMV mechanism for evading antiviral innate immunity through its encoded microRNA by targeting transmembrane glycoprotein CD147, and a potential cause of HCMV inflammatory disorders due to the secretion of proinflammatory cytokine CyPA.

Indexed as

Gene Expression RegulationHost-Pathogen InteractionsBasiginCell LineCytomegalovirusHumansImmune EvasionInterferon-betaMicroRNAsNF-kappa BRNA, ViralBasiginBSG protein, humanInterferon-betaMicroRNAsNF-kappa BRNA, ViralCD147/EMMPRINcyclophilin A (CyPA)ERK/NF-κB signaling pathwayHCMV inflammatory disordershuman cytomegalovirus (HCMV)miR-US25-1-5p

Identifiers

PMID29194430
PMCPMC5744140
OpenAlexW2773466365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.