Evidence map›Paper›PMID 29194424›Full record

ReviewNutrients2017

Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management.

Ahmad Alkhatib, Catherine Tsang, Ali Tiss, Theeshan Bahorun, Hossein Arefanian, Roula Barake, Abdelkrim Khadir, Jaakko Tuomilehto

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07505212 (Exploring Tannin-Probiotic Interactions on Microbial Composition and Inflammatory Outcomes in Obesity), which is not on this map. Cited by 152 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 4 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07505212 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Exploring Tannin-Probiotic Interactions on Microbial Composition and Inflammatory Outcomes in Obesity

TypeinterventionalSponsorPrairie View A&M UniversityRan2026 to 2026Enrolled20ConditionsObesity (Disorder)ArmsGallotannin-rich mango, Lactiplantibacillus pentosus (probiotic), No Treatment Added
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 4 syntheses or guidelines pooled it, 359 citations in OpenAlex.

  1. Pooled it
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  18. Nutrients · 2026
    Review
  19. Review
  20. A Novel Blend ofFoods (Basel, Switzerland) · 2026
    Article

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Ahmad AlkhatibDasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. drahmadalkhatib@gmail.com.
Catherine TsangFaculty of Health and Social Care, Edge Hill University, St. Helens Road, Ormskirk, Lancashire L39 4QP, UK. Tsang@edgehill.ac.uk.
Ali TissDasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. ali.tiss@dasmaninstitute.org.
Theeshan BahorunANDI Centre of Excellence for Biomedical and Biomaterials Research, University of Mauritius, MSIRI Building, Réduit 80837, Mauritius. tbahorun@uom.ac.mu.
Hossein ArefanianDasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. hossein.arefanian@dasmaninstitute.org.
Roula BarakeDasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. roula.barake@dasmaninstitute.org.
Abdelkrim KhadirDasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. abdelkrim.khadir@dasmaninstitute.org.
Jaakko TuomilehtoDasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. jaakko.tuomilehto@dasmaninstitute.org.
Dasman Diabetes Institute · KWEdge Hill University · GBKing Abdulaziz University · SAMauritius Sugarcane Industry Research Institute · MU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as type 2 diabetes mellitus (T2DM). A regular consumption of functional foods may be associated with enhanced anti-oxidant, anti-inflammatory, insulin sensitivity, and anti-cholesterol functions, which are considered integral to prevent and manage T2DM. Components of the Mediterranean diet (MD)-such as fruits, vegetables, oily fish, olive oil, and tree nuts-serve as a model for functional foods based on their natural contents of nutraceuticals, including polyphenols, terpenoids, flavonoids, alkaloids, sterols, pigments, and unsaturated fatty acids. Polyphenols within MD and polyphenol-rich herbs-such as coffee, green tea, black tea, and yerba maté-have shown clinically-meaningful benefits on metabolic and microvascular activities, cholesterol and fasting glucose lowering, and anti-inflammation and anti-oxidation in high-risk and T2DM patients. However, combining exercise with functional food consumption can trigger and augment several metabolic and cardiovascular protective benefits, but it is under-investigated in people with T2DM and bariatric surgery patients. Detecting functional food benefits can now rely on an "omics" biological profiling of individuals' molecular, genetics, transcriptomics, proteomics, and metabolomics, but is under-investigated in multi-component interventions. A personalized approach for preventing and managing T2DM should consider biological and behavioral models, and embed nutrition education as part of lifestyle diabetes prevention studies. Functional foods may provide additional benefits in such an approach.

Indexed as

Functional FoodLife StyleDiabetes Mellitus, Type 2Diet, MediterraneanHumansbariatric surgeryfunctional foodgreen teaMediterranean dietnutrition counsellingphysical activitypolyphenolstype 2 diabetes mellitusyerba mate

Identifiers

PMID29194424
PMCPMC5748760
OpenAlexW2772650360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.