Trial reportShock (Augusta, Ga.)2018
Risk Factors for the Development of Acute Respiratory Distress Syndrome Following Hemorrhage.
Trial report in Shock (Augusta, Ga.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Prehospital coagulation management and fluid replacement therapy in patients with multiple and/or severe injuries - A systematic review and clinical practice guideline update.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).Annals of the American Thoracic Society · 2022Trial
- Group A emergency-release plasma in trauma patients requiring massive transfusion.The journal of trauma and acute care surgery · 2020Trial
- Association between intraoperative fluid volume and 30-day mortality in patients undergoing lung transplantation: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Early Prediction of Acute Respiratory Distress Syndrome in Critically Ill Polytrauma Patients Using Balanced Random Forest ML: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Acute Respiratory Distress Syndrome: Pathophysiological Insights, Subphenotypes, and Clinical Implications-A Comprehensive Review.Journal of clinical medicine · 2025Review
- An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome.Critical care medicine · 2025Article
- Early Fluid Is Less Fluid: Comparing Early Versus Late ICU Resuscitation in Severely Injured Trauma Patients.Critical care explorations · 2024Observational
- Effect of parachute delivery on red blood cell (RBC) and plasma quality measures of blood for transfusion.Transfusion · 2021Article
- Risk Factors Analysis of Thoracic Trauma Complicated With Acute Respiratory Distress Syndrome and Observation of Curative Effect of Lung-Protective Ventilation.Frontiers in surgery · 2021Article
- Fluid Therapy in Pulmonary Disease: How Careful Do We Need to Be?Frontiers in veterinary science · 2021Review
- Is chest imaging relevant in diagnosing acute respiratory distress syndrome in polytrauma patients? A population-based cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Transfusion in the mechanically ventilated patient.Intensive care medicine · 2020Review
- Intense Light Pretreatment Improves Hemodynamics, Barrier Function and Inflammation in a Murine Model of Hemorrhagic Shock Lung.Military medicine · 2020Article
- Minor change in initial PEEP setting decreases rates of ventilator-associated events in mechanically ventilated trauma patients.Trauma surgery & acute care open · 2020Article
- Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation.The journal of trauma and acute care surgery · 2019Article
- Optimal crystalloid volume ratio for blood replacement for maintaining hemodynamic stability and lung function: an experimental randomized controlled study.BMC anesthesiology · 2019Article
- Higher intraoperative plasma transfusion volumes are associated with inferior perioperative outcomes.Transfusion · 2019Article
- Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.The Journal of surgical research · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundThe Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) study evaluated the effects of plasma and platelets on hemostasis and mortality after hemorrhage. The pulmonary consequences of resuscitation strategies that mimic whole blood, remain unknown.
methodsA secondary analysis of the PROPPR study was performed. Injured patients predicted to receive a massive transfusion were randomized to 1:1:1 versus 1:1:2 plasma-platelet-red blood cell ratios at 12 Level I North American trauma centers. Patients with survival >24 h, an intensive care unit (ICU) stay, and a recorded PaO2/FiO2 (P/F) ratio were included. Acute respiratory distress syndrome (ARDS) was defined as a P/F ratio < 200, with bilateral pulmonary infiltrates, and adjudicated by investigators.
resultsFour hundred fifty-four patients were reviewed (230 received 1:1:1, 224 1:1:2). Age, sex, injury mechanism, and regional abbreviated injury scale (AIS) scores did not differ between cohorts. Tidal volume, positive end-expiratory pressure, and lowest P/F ratio did not differ. No significant differences in ARDS rates (14.8% vs. 18.4%), ventilator-free (24 vs. 24) or ICU-free days (17.5 vs. 18), hospital length of stay (22 days vs. 18 days), or 30-day mortality were found (28% vs. 28%). ARDS was associated with blunt injury (OR 3.61 [1.53-8.81] P < 0.01) and increasing chest AIS (OR 1.40 [1.15-1.71] P < 0.01). Each 500 mL of crystalloid infused during hours 0 to 6 was associated with a 9% increase in the rate of ARDS (OR 1.09 [1.04-1.14] P < 0.01). Blood given at 0 to 6 or 7 to 24 h were not risk factors for lung injury.
conclusionAcute crystalloid exposure, but not blood products, is a potentially modifiable risk factor for the prevention of ARDS following hemorrhage.
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Registered trials
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