Evidence map›Paper›PMID 29193888›Full record

ArticleArthritis care & research2018

Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction.

Steven Pfeiffer, Matthew S Harkey, Laura E Stanley, J Troy Blackburn, Darin A Padua, Jeffrey T Spang, Stephen W Marshall, Joanne M Jordan, Randy Schmitz, Daniel Nissman and 1 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Arthritis care & research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04906499 (Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04906499 nacompletednot on this mapstarted 2021, after this paper: background citation

Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2021 to 2022Enrolled7ConditionsAnterior Cruciate Ligament Injuries, Exercise, Cartilage, Articular, Knee InjuriesArmsPhysical Activity Promotion
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Peak Vertical Ground Reaction Force Modifies Gait Biomechanics Bilaterally Following ACL Reconstruction: A Randomized Experiment.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Trial
  3. Trial
  4. Trial
  5. Article
  6. Gait Biomechanical Profiles Following Anterior Cruciate Ligament Reconstruction in Sexually-Immature Pediatrics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Aberrant Gait Biomechanics Linked to Cartilage Changes After ACL Reconstruction in Those With High Body Mass Index.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  11. Article
  12. Article
  13. Bilateral waveform analysis of gait biomechanics presurgery to 12 months following ACL reconstruction compared to controls.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Linking Gait Biomechanics and Daily Steps After ACL Reconstruction.Medicine and science in sports and exercise · 2022
    Article
  20. Knee joint unloading and daily physical activity associate with cartilage T2 relaxation times 1 month after ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Steven PfeifferUniversity of North Carolina, Chapel Hill.
Matthew S HarkeyUniversity of North Carolina, Chapel Hill.
Laura E StanleyUniversity of North Carolina, Chapel Hill.
J Troy BlackburnUniversity of North Carolina, Chapel Hill.
Darin A PaduaUniversity of North Carolina, Chapel Hill.
Jeffrey T SpangUniversity of North Carolina, Chapel Hill.
Stephen W MarshallUniversity of North Carolina, Chapel Hill.
Joanne M JordanUniversity of North Carolina, Chapel Hill.
Randy SchmitzUniversity of North Carolina, Chapel Hill.
Daniel NissmanUniversity of North Carolina, Chapel Hill.
Brian PietrosimoneUniversity of North Carolina, Chapel Hill.
University of North Carolina at Chapel Hill · US

Funding

Posttraumatic Osteoarthritis: Establishing a Comprehensive Evaluation StrategyR03AR066840 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIETROSIMONE, BRIAN · 2015 to 2016
$152k
NIAMS NIH HHS R03 AR066840
6 · The paper itself

Abstract

objectiveTo determine whether walking speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR.

methodsTwenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m

resultsSlower walking speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = -0.51, P = 0.02; central MFC, r = -0.47, P = 0.04). Similarly, slower walking speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = -0.47, P = 0.04) 12 months following ACLR.

conclusionSlower walking speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR.

Indexed as

Imaging, Three-DimensionalAdultAge FactorsAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionArthroscopyCartilage, ArticularFemaleFollow-Up StudiesHumansInjury Severity ScoreMagnetic Resonance ImagingMaleRecovery of FunctionSex FactorsTime Factors

Identifiers

PMID29193888
PMCPMC5972050
OpenAlexW2770955388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.