Evidence map›Paper›PMID 29193852›Full record

ArticleCPT: pharmacometrics & systems pharmacology2017

Frequency-Domain Response Analysis for Quantitative Systems Pharmacology Models.

Pascal Schulthess, Teun M Post, James Yates, Piet H van der Graaf

Abstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. In vitro and in silico analysis of the effects of DBritish journal of pharmacology · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pascal SchulthessSystems Biomedicine & Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.
Teun M PostSystems Biomedicine & Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.
James YatesDMPK, Oncology, Innovative Medicines and Early Development, AstraZeneca, Chesterford Research Park, UK.ORCID http://orcid.org/0000-0003-0433-5900
Piet H van der GraafSystems Biomedicine & Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug dosing regimen can significantly impact drug effect and, thus, the success of treatments. Nevertheless, trial and error is still the most commonly used method by conventional pharmacometric approaches to optimize dosing regimen. In this tutorial, we utilize four distinct classes of quantitative systems pharmacology models to introduce frequency-domain response analysis, a method widely used in electrical and control engineering that allows the analytical optimization of drug treatment regimen from the dynamics of the model.

Identifiers

PMID29193852
PMCPMC5824121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.