Evidence map›Paper›PMID 29193845›Full record

ArticleChemMedChem2018

Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution.

Brian M Cawrse, Rena S Lapidus, Brandon Cooper, Eun Yong Choi, Katherine L Seley-Radtke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brian M CawrseDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA.
Rena S LapidusTranslational Laboratory Shared Service, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA.
Brandon CooperTranslational Laboratory Shared Service, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA.
Eun Yong ChoiTranslational Laboratory Shared Service, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA.
Katherine L Seley-RadtkeDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA.ORCID 0000-0002-0154-3459
University of Maryland, Baltimore · USUniversity of Maryland, Baltimore County · US

Funding

Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Fused Pyrimidine (IsoA) Nucleosides:Design and SynthesisR01CA097634 · NCI · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI RADTKE, KATHERINE L. · 2002 to 2006
$1.5M
Unnatural Base Pairs as DNA BioprobesR01GM073645 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L · 2005 to 2009
$1.1M
NCI NIH HHS R01 CA097634NIGMS NIH HHS R01 GM073645NIGMS NIH HHS T32 GM066706
6 · The paper itself

Abstract

Halogenated pyrrolo[3,2-d]pyrimidine analogues have shown antiproliferative activity in recent studies, with cell accumulation occurring in the G

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalDNA DamageDose-Response Relationship, DrugDrug Screening Assays, AntitumorHalogenationHumansMaximum Tolerated DoseMicePyrimidinesPyrrolesStructure-Activity RelationshipAntineoplastic AgentsPyrimidinesPyrrolesanticancerantiproliferativeprodrugspyrrolopyrimidinestriple-negative breast cancer

Identifiers

PMID29193845
PMCPMC5912934
OpenAlexW2768860395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.