ArticleBJOG : an international journal of obstetrics and gynaecology2018
The incidence, characteristics, management and outcomes of anaphylaxis in pregnancy: a population-based descriptive study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 53 citations in OpenAlex.
- Gene Factors and Serotypes Related to Polysaccharide and Protein-Based Candidate Vaccines AmongCurrent issues in molecular biology · 2026Article
- Use of evidence from the UK Obstetric Surveillance System in policy and clinical practice: a descriptive study using citation tracking.NIHR open research · 2026Article
- Successful desensitization to liposomal amphotericin B for the treatment of disseminated cryptococcosis in pregnancy: a case report.ASM case reports · 2026Article
- Anaphylaxis and pregnancy: Epidemiology, elicitors, and recurrences.The World Allergy Organization journal · 2025Article
- Effectiveness and safety of algorithm for treating pregnant women with syphilis and history of immediate allergy to penicillin.The journal of allergy and clinical immunology. Global · 2025Article
- Successful management of anaphylactic shock prior to elective cesarean delivery: a case report.JA clinical reports · 2024Article
- Anaphylaxis-induced premature uterine contractions: a case report and literature review.BMC pregnancy and childbirth · 2024Review
- Sudden respiratory and circulatory collapse after cesarean section: Amniotic fluid embolism or other reasons? - a case report.BMC pregnancy and childbirth · 2022Article
- Vancomycin during delivery hospitalizations for women with group B streptococcus.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Two lives at stake: Obstetric anaphylactic shock resulting in acute respiratory distress syndrome - A case report.SAGE open medical case reports · 2022Article
- Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes.Journal of personalized medicine · 2021Review
- State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics.Life (Basel, Switzerland) · 2021Review
- Algorithm to guide re-exposure to penicillin in allergic pregnant women with syphilis: Efficacy and safety.The World Allergy Organization journal · 2021Article
- Maternal critical care: part I.BJA education · 2021Review
- Successful Management of a Suspected Case of Meperidine-Induced Anaphylaxis in Cesarean Delivery.Anesthesiology and pain medicine · 2020Article
- The incidence, characteristics, management and outcomes of anaphylaxis in pregnancy: a population-based descriptive study.BJOG : an international journal of obstetrics and gynaecology · 2018Article
- [Update on perioperative hypersensitivity reactions: joint document of the Brazilian Society of Anesthesiology (SBA) and Brazilian Association of Allergy and Immunology (ASBAI) - Part I: post-crisis guidelines and treatment].Brazilian journal of anesthesiology (Elsevier)Review
- To screen or not to screen women for Group B Streptococcus (Therapeutic advances in infectious diseaseReview
- Anaphylaxis in Pregnancy in the United States: Risk Factors and Temporal Trends Using National Routinely Collected Data.The journal of allergy and clinical immunology. In practiceArticle
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to estimate the incidence of anaphylaxis in pregnancy and describe the management and outcomes in the UK.
designA population-based descriptive study using the UK Obstetric Surveillance System (UKOSS).
settingAll consultant-led maternity units in the UK. POPULATION: All pregnant women who had anaphylaxis between 1 October 2012 and 30 September 2015. Anaphylaxis was defined as a severe, life-threatening generalised or systemic hypersensitivity reaction.
methodsProspective case notification using UKOSS.
main outcome measuresMaternal mortality, severe maternal morbidity, neonatal mortality and severe neonatal morbidity.
resultsThere were 37 confirmed cases of anaphylaxis in pregnancy, giving an estimated incidence of 1.6 (95% CI: 1.1-2.2) per 100 000 maternities. Four cases of anaphylaxis were in women with known penicillin allergies: two received co-amoxiclav and two cephalosporins. Twelve women had anaphylaxis following prophylactic use of antibiotics at the time of a caesarean delivery. Prophylactic use of antibiotics for Group B streptococcal infection accounted for anaphylaxis in one woman. Two women died (5%), 14 (38%) women were admitted to intensive care and seven women (19%) had one or more additional severe maternal morbidities, which included three haemorrhagic events, two cardiac arrests, one thrombotic event and one pneumonia. No infants died; however, in those infants whose mother had anaphylaxis before delivery (n = 18) there were seven (41%) neonatal intensive care unit admissions, three preterm births and one baby was cooled for neonatal encephalopathy.
conclusionsAnaphylaxis is a rare severe complication of pregnancy and frequently the result of a reaction to antibiotic administration. This study highlights the seriousness of the outcomes of this condition for the mother. The low incidence is reassuring given the large proportion of the pregnant population that receive prophylactic antibiotics during delivery. TWEETABLE ABSTRACT: Anaphylaxis is a rare severe complication of pregnancy and frequently the result of a reaction to antibiotic administration.
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