Evidence map›Paper›PMID 29193576›Full record

Trial reportEuropean journal of heart failure2018

Adaptive servo-ventilation for central sleep apnoea in systolic heart failure: results of the major substudy of SERVE-HF.

Martin R Cowie, Holger Woehrle, Karl Wegscheider, Eik Vettorazzi, Susanne Lezius, Wolfgang Koenig, Frank Weidemann, Gillian Smith, Christiane Angermann, Marie-Pia d'Ortho and 6 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Observational
  10. The Pathogenesis of Central and Complex Sleep Apnea.Current neurology and neuroscience reports · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Article
  19. Monitoring for sleep-disordered breathing in heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2019
    Article
  20. Cardiac adrenergic neuronal activity, sleep apnea, and potential therapeutic role of nocturnal ventilatory assistance in patients with heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 4 countries.

Martin R CowieImperial College London, London, UK.
Holger WoehrleResMed Science Centre, ResMed Germany Inc., Martinsried, Germany.
Karl WegscheiderDepartment of Medical Biometry and Epidemiology, University Medical Center Eppendorf, Hamburg, Germany.
Eik VettorazziDepartment of Medical Biometry and Epidemiology, University Medical Center Eppendorf, Hamburg, Germany.
Susanne LeziusDepartment of Medical Biometry and Epidemiology, University Medical Center Eppendorf, Hamburg, Germany.
Wolfgang KoenigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Frank WeidemannDepartment of Medicine I, University and University Hospital Würzburg, Würzburg, Germany.
Gillian SmithRoyal Brompton Hospital, London, UK.
Christiane AngermannComprehensive Heart Failure Center, University Hospital and University of Würzburg, Würzburg, Germany.
Marie-Pia d'OrthoUniversity Paris Diderot, Sorbonne Paris Cité, Hôpital Bichat, Explorations Fonctionnelles, DHU FIRE, AP-HP, Paris, France.
Erland ErdmannHeart Center, University of Cologne, Cologne, Germany.
Patrick LevyCHU de Grenoble, Grenoble, France.
Anita K SimondsRoyal Brompton Hospital, London, UK.
Virend K SomersMayo Clinic and Mayo Foundation, Rochester, MN, USA.
Faiez ZannadInserm, Université de Lorraine, CHU, Nancy, France.
Helmut TeschlerDepartment of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
University Medical Center Hamburg-Eppendorf · DERoyal Brompton Hospital · GBHôpital Bichat-Claude-Bernard · FRImperial College London · GBKatharinenhospital · DEMayo Clinic · USResMed (Germany) · DERuhrlandklinik · DEUniversité de Lorraine · FRUniversité Grenoble Alpes · FRUniversity Hospital Ulm · DEUniversity of Cologne · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe SERVE-HF trial investigated the impact of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with systolic heart failure. A preplanned substudy was conducted to provide insight into mechanistic changes underlying the observed effects of ASV, including assessment of changes in left ventricular function, ventricular remodelling, and cardiac, renal and inflammatory biomarkers. METHODS AND

resultsIn a subset of the 1325 randomised patients, echocardiography, cardiac magnetic resonance imaging (cMRI) and biomarker analysis were performed at baseline, and 3 and 12 months. In secondary analyses, data for patients with baseline and 12-month values were evaluated; 312 patients participated in the substudy. The primary endpoint, change in echocardiographically determined left ventricular ejection fraction from baseline to 12 months, did not differ significantly between the ASV and the control groups. There were also no significant between-group differences for changes in left ventricular dimensions, wall thickness, diastolic function or right ventricular dimensions and ejection fraction (echocardiography), and on cMRI (in small patient numbers). Plasma N-terminal pro B-type natriuretic peptide concentration decreased in both groups, and values were similar at 12 months. There were no significant between-group differences in changes in cardiac, renal and systemic inflammation biomarkers.

conclusionIn patients with systolic heart failure and CSA, addition of ASV to guideline-based medical management had no statistically significant effect on cardiac structure and function, or on cardiac biomarkers, renal function and systemic inflammation over 12 months. The increased cardiovascular mortality reported in SERVE-HF may not be related to adverse remodelling or worsening heart failure.

Indexed as

AgedEchocardiographyFemaleFollow-Up StudiesHeart Failure, SystolicHeart VentriclesHumansMagnetic Resonance Imaging, CineMalePositive-Pressure RespirationSleep Apnea, CentralStroke VolumeTreatment OutcomeVentricular Function, LeftAdaptive servo-ventilationBiomarkersCardiac functionCentral sleep apnoeaHeart failure

Identifiers

PMID29193576
OpenAlexW2773426667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.