ArticleHuman brain mapping2018
Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Resting-state functional connectivity alterations in dementia with Lewy bodies: a systematic review and activation likelihood estimation meta-analysis.Brain imaging and behavior · 2026Pooled it
- (Dis-)Connected Dots in Dementia with Lewy Bodies-A Systematic Review of Connectivity Studies.Movement disorders : official journal of the Movement Disorder Society · 2023Pooled it
- Neuroimaging alterations in dementia with Lewy bodies and neuroimaging differences between dementia with Lewy bodies and Alzheimer's disease: An activation likelihood estimation meta-analysis.CNS neuroscience & therapeutics · 2022Pooled it
- Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Assessing subcortical, brainstem and cerebellar metabolic patterns using [18F]FDG PET-CT imaging in dementia with Lewy bodies.European journal of nuclear medicine and molecular imaging · 2026Article
- Network based statistics associates increased connectivity to REM sleep disorder and hallucinations in early DLB.NPJ Parkinson's disease · 2026Article
- MCI-LB brain networks reorganization in relation to specific cognitive domains deficits.Scientific reports · 2026Article
- Wavelet event-related EEG phase coherence as a discriminant biomarker of the cognitive status in Parkinson's and Lewy body disease.Frontiers in human neuroscience · 2026Article
- Network hierarchy in Alzheimer's and Lewy body spectrum disorders: functional gradients, cognitive phenotypes, and translational gaps.Frontiers in aging neuroscience · 2026Review
- A spatial covarianceJournal of neurology · 2025Article
- Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation.Alzheimer's research & therapy · 2025Article
- Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer's and Lewy body disease.Brain : a journal of neurology · 2025Article
- Sentence comprehension in Lewy body diseases: a functional magnetic resonance imaging study.Brain communications · 2025Article
- Atypical Parkinsonian Syndromes: Structural, Functional, and Molecular Imaging Features.AJNR. American journal of neuroradiology · 2024Review
- Attention Network Dysfunctions in Lewy Body Dementia and Alzheimer's Disease.Journal of clinical medicine · 2024Article
- Abnormal EEG microstates in Alzheimer's disease: predictors of β-amyloid deposition degree and disease classification.GeroScience · 2024Article
- Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.Current neurology and neuroscience reports · 2024Review
- Association between patent foramen ovale and migraine: evidence from a resting-state fMRI study.Brain imaging and behavior · 2024Article
- Changes of neural coupling between cognitive and motor networks associated with dual-task performance in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies.NeuroImage · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations in functional connectivity within and between brain networks. This resting-state study sought to clarify this in DLB, how networks differed from Alzheimer's disease (AD), and whether they were related to clinical symptoms in DLB. Resting-state networks were estimated using independent component analysis. We investigated functional connectivity changes in 31 DLB patients compared to 31 healthy controls and a disease comparator group of 29 AD patients using dual regression and FSLNets. Within-network connectivity was generally decreased in DLB compared to controls, mainly in motor, temporal, and frontal networks. Between-network connectivity was mainly intact; only the connection between a frontal and a temporal network showed increased connectivity in DLB. Differences between AD and DLB were subtle and we did not find any significant correlations with the severity of clinical symptoms in DLB. This study emphasizes the importance of reduced connectivity within motor, frontal, and temporal networks in DLB with relative sparing of the default mode network. The lack of significant correlations between connectivity measures and clinical scores indicates that the observed reduced connectivity within these networks might be related to the presence, but not to the severity of motor and cognitive impairment in DLB patients. Furthermore, our results suggest that AD and DLB may show more similarities than differences in patients with mild disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.