Evidence map›Paper›PMID 29193448›Full record

ArticleNMR in biomedicine2018

Increased CEST specificity for amide and fast-exchanging amine protons using exchange-dependent relaxation rate.

Xiao-Yong Zhang, Feng Wang, Junzhong Xu, Daniel F Gochberg, John C Gore, Zhongliang Zu

Abstract read
In one paragraph

Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Effective Modeling of Continuous WaveMagnetic resonance in medicine · 2026
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  17. Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021
    Review
  18. Article
  19. Characterization of BPhysics in medicine and biology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao-Yong ZhangVanderbilt University Institute of Imaging Science, Nashville, TN, USA.ORCID 0000-0001-8965-1077
Feng WangVanderbilt University Institute of Imaging Science, Nashville, TN, USA.
Junzhong XuVanderbilt University Institute of Imaging Science, Nashville, TN, USA.
Daniel F GochbergVanderbilt University Institute of Imaging Science, Nashville, TN, USA.ORCID 0000-0003-3708-1310
John C GoreVanderbilt University Institute of Imaging Science, Nashville, TN, USA.
Zhongliang ZuVanderbilt University Institute of Imaging Science, Nashville, TN, USA.ORCID 0000-0001-7361-7480

Funding

MRI Diffusion in Tumors Using Oscillating GradientsR01CA109106 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2006 to 2022
$4.0M
CERT Imaging of CancerR01CA184693 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2018
$1.6M
CERT Imaging of MuscleR01EB017767 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2017
$1.4M
MRI of Mobile Protein and Immobile Metabolite via Magnetization Rotation TransferR21EB017873 · NIBIB · VANDERBILT UNIVERSITY · PI ZU, ZHONGLIANG · 2013 to 2014
$424k
NCI NIH HHS R01 CA109106NCI NIH HHS R01 CA184693NIBIB NIH HHS R01 EB017767NIBIB NIH HHS R21 EB017873
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) imaging of amides at 3.5 ppm and fast-exchanging amines at 3 ppm provides a unique means to enhance the sensitivity of detection of, for example, proteins/peptides and neurotransmitters, respectively, and hence can provide important information on molecular composition. However, despite the high sensitivity relative to conventional magnetic resonance spectroscopy (MRS), in practice, CEST often has relatively poor specificity. For example, CEST signals are typically influenced by several confounding effects, including direct water saturation (DS), semi-solid non-specific magnetization transfer (MT), the influence of water relaxation times (T

Indexed as

Magnetic Resonance ImagingProtonsAmidesAminesAnimalsBrainRatsAmidesAminesProtonsAPTCESTfast-exchanging amineMRIspecificity

Identifiers

PMID29193448
PMCPMC5773365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.