ArticleLasers in surgery and medicine2018
Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography.
Article in Lasers in surgery and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- 3D Measurement of Chronic Wounds in Routine Care: A Review with Practical Guidance for Smartphone Photogrammetry.Annals of biomedical engineering · 2026Review
- Using spatial frequency domain imaging to monitor a skin biopsy wound: a pilot study.Biomedical optics express · 2024Article
- Visualization enhancement by PCA-based image fusion for skin burns assessment in polarization-sensitive OCT.Biomedical optics express · 2024Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- Deep-learning approach for automated thickness measurement of epithelial tissue and scab using optical coherence tomography.Journal of biomedical optics · 2022Article
- Polarization state tracing method to map local birefringent properties in samples using polarization sensitive optical coherence tomography.Biomedical optics express · 2020Article
- Stable fiber-based polarization-sensitive optical coherence tomography using polarization maintaining common-path interferometer.Journal of biomedical optics · 2020Article
- Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts.Biomedical optics express · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveWound healing involves a complex and dynamic biological process in response to tissue injury. Monitoring of the cascade of cellular events is useful for wound management and treatment. The aim of this study is to demonstrate the potential of multifunctional polarization-sensitive optical coherence tomography (PS-OCT) to longitudinally monitor the self-healing process in a murine cutaneous wound model. MATERIALS AND
methodsA multi-functional PS-OCT system based on swept source OCT configuration (1,310 nm central wavelength) was designed to obtain simultaneously microstructural, blood perfusion, and birefringent information of a biological tissue in vivo. A 1-mm-diameter wound was generated in a mouse pinna with a complete biopsy punch. Afterwards, the self-healing process of the injured tissue was observed every week over 6-week period using the multifunctional system to measure changes in the tissue birefringence. Further OCT angiography (OCTA) was used in post data processing to obtain blood perfusion information over the injured tissue.
resultsThree complementary images indicating the changes in anatomical, vascular, and birefringent information of tissue around wound were simultaneously provided from a 3-dimensional (3-D) PS-OCT data set during the wound repair over 1 month. Specifically, inflammatory and proliferative phases of wound healing were characterized by thickened epidermal tissue (from OCT images) and angiogenesis (from OCT angiography images) around wound. Also, it was observed that the regenerating tissues had highly realigned birefringent structures (from PS-OCT images).
conclusionThis preliminary study suggests that the proposed multi-functional imaging modality has a great potential to improve the understanding of wound healing through non-invasive, serial monitoring of vascular and tissue responses to injury. Lasers Surg. Med. 50:213-221, 2018. © 2017 Wiley Periodicals, Inc.
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