Evidence map›Paper›PMID 29193076›Full record

ArticleThe Journal of physiology2018

Resurgent sodium current promotes action potential firing in the avian auditory brainstem.

Hui Hong, Ting Lu, Xiaoyu Wang, Yuan Wang, Jason Tait Sanchez

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Inhibition of Voltage-Gated NaInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
  6. Resurgent NaNature communications · 2021
    Article
  7. Persistent and resurgent NaJournal of neurophysiology · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hui HongRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-2963-3771
Ting LuRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0001-8114-8469
Xiaoyu WangDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, 32306, USA.
Yuan WangDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, 32306, USA.
Jason Tait SanchezRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0003-0115-846X
Northwestern University · USFlorida State University · US

Funding

Development and afferent regulation of auditory neuronsR01DC013074 · NIDCD · UNIVERSITY OF WASHINGTON · PI WANG, YUAN · 2014 to 2018
$1.9M
Mechanisms Regulating Synaptic Function in the Developing Auditory SystemR03DC013841 · NIDCD · NORTHWESTERN UNIVERSITY · PI SANCHEZ, JASON TAIT · 2015 to 2017
$464k
NIDCD NIH HHS R01 DC013074NIDCD NIH HHS R03 DC013841
6 · The paper itself

Abstract

key pointsAuditory brainstem neurons of all vertebrates fire phase-locked action potentials (APs) at high rates with remarkable fidelity, a process controlled by specialized anatomical and biophysical properties. This is especially true in the avian nucleus magnocellularis (NM) - the analogue of the mammalian anteroventral cochlear nucleus. In addition to high voltage-activated potassium (K ABSTRACT: Auditory brainstem neurons are functionally primed to fire action potentials (APs) at markedly high rates in order to rapidly encode the acoustic information of sound. This specialization is critical for survival and the comprehension of behaviourally relevant communication functions, including sound localization and distinguishing speech from noise. Here, we investigated underlying ion channel mechanisms essential for high-rate AP firing in neurons of the chicken nucleus magnocellularis (NM) - the avian analogue of bushy cells of the mammalian anteroventral cochlear nucleus. In addition to the established function of high voltage-activated potassium channels, we found that resurgent sodium current (I

Indexed as

Action PotentialsAnimalsBasal Nucleus of MeynertBrain StemChick EmbryoChickensEvoked Potentials, Auditory, Brain StemFemaleHearingMaleNeuronsSodiumSodium ChannelsSodiumSodium Channelsaction potentialauditory systemdevelopmentneuronnucleus magnocellularispotassium channelsodium channel

Identifiers

PMID29193076
PMCPMC5792585
OpenAlexW2795056070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.