Evidence map›Paper›PMID 29192673›Full record

ArticleCell research2018

TRFH domain: at the root of telomere protein evolution?

Marie-Joseph Giraud-Panis, Jing Ye, Eric Gilson

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marie-Joseph Giraud-PanisUniversité Côte d'Azur, CNRS UMR7284; Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice 06107, France.
Jing YeInternational Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital/CNRS/Inserm/Nice University, Pôle Sino-Français de Recherche en Sciences du Vivant et Génomique, Shanghai, China.
Eric GilsonUniversité Côte d'Azur, CNRS UMR7284; Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice 06107, France.
Shanghai Jiao Tong University · CNInstitut de Recherche sur le Cancer et le Vieillissement de Nice · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two articles in Cell Research focus on the structure-function relationships in the shelterin complex that binds to telomeres and is essential for their stability and functions. These studies concerning both mammalian and Schizosaccharomyces pombe proteins reveal unexpected structural conservation of a motif called TRFH (Telomeric Repeat Factors Homology) domain between several subunits in these complexes, providing a rationale for further dissection of the role of telomeres in chromosome stability, aging and cancer, and encouraging us to revisit the evolution of telomere proteins.

Indexed as

SchizosaccharomycesAnimalsCarrier ProteinsDNA-Binding ProteinsSchizosaccharomyces pombe ProteinsShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2Carrier ProteinsDNA-Binding ProteinsPoz1 protein, S pombeRap1 protein, S pombeSchizosaccharomyces pombe ProteinsShelterin ComplexTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2Tpz1 protein, S pombe

Identifiers

PMID29192673
PMCPMC5752847
OpenAlexW2772217404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.