ReviewAnnals of intensive care2017
Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critically [corrected] ill patients?
Review in Annals of intensive care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit
Impaired Platelet Reactivity as an Early Biomarker for Sepsis-related Thrombocytopenia
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.
- Impact of antiplatelet therapy on outcomes of sepsis: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Article
- Explainable machine learning-based 28-day mortality prediction model for elderly patients with acute kidney injury.BMC nephrology · 2026Article
- Non-anticoagulant heparin attenuates histone-mediated platelet-leukocyte aggregation and neutrophil extracellular trap formation in a canine whole blood model.Frontiers in veterinary science · 2026Article
- Acquired platelet dysfunction induced by infection in an older patient: Severe hemorrhage despite normal platelet count.SAGE open medical case reports · 2026Article
- A Predictive Model for Moderate or Severe Neonatal Acute Respiratory Distress Syndrome in Extremely Preterm Infants with Premature Rupture of Membranes: Development and Internal Validation.Journal of inflammation research · 2026Article
- P-Selectin and Platelet-Monocyte Interaction in Inflammation: Mechanisms, Hypothesis, and Open Questions.Journal of inflammation research · 2026Review
- Dynamic platelet profiles in the emergency department and their predictive value for 28-day all-cause mortality in septic patients.PloS one · 2026Article
- Stratified assessment of platelets in sepsis: from dynamic counts to functional phenotypes.Frontiers in immunology · 2026Review
- Article
- Comparative evaluation of the aggregate index of systemic inflammation (AISI) and its modified version for early detection of central line-associated bloodstream infection: a pilot study using machine learning techniques.GMS hygiene and infection control · 2026Article
- Posttransfusion recovery, quality, and metabolism of short- and long-term stored platelets during controlled inflammation.Blood advances · 2025Article
- Change in platelet and leukocyte counts and hospital mortality in adults with acute kidney injury receiving continuous renal replacement therapy.Scientific reports · 2025Article
- Prostate Tissue-Induced Platelet Activation and Platelet-Neutrophil Aggregation Following Transurethral Resection of the Prostate Surgery: An In Vitro Study.Biomedicines · 2025Article
- Exosomes and MicroRNAs: key modulators of macrophage polarization in sepsis pathophysiology.European journal of medical research · 2025Review
- Role of Liver Kinase 1B in Platelet Activation and Host Defense DuringInternational journal of molecular sciences · 2025Article
- Association of PIV value with early mortality in ICU patients with sepsis-associated acute kidney injury from the MIMIC IV database.Scientific reports · 2025Article
- Haemophagocytic lymphohistiocytosis in critically ill adults: a single-centre retrospective ICU cohort study.Frontiers in medicine · 2025Article
- Early prediction of sepsis-induced coagulopathy in the ICU using interpretable machine learning: a multi-center retrospective cohort study.Frontiers in medicine · 2025Article
- The Crucial Roles of Platelets as Immune Mediators in Sepsis.Journal of inflammation research · 2025Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.