ArticleScientific reports2017
Higher Platelet-to-Lymphocyte Ratio Increased the Risk of Sarcopenia in the Community-Dwelling Older Adults.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.Nature communications · 2021Pooled it
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- The association between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus.Irish journal of medical science · 2026Article
- Evaluation of ten composite inflammatory indicators for sarcopenia in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Systemic immune-inflammation index as a prognostic biomarker in critically ill dogs.Frontiers in veterinary science · 2026Article
- Association between the ratio of uric acid to high-density lipoprotein cholesterol (UHR) and the abnormal risk of sarcopenia: Evidence from two large population-based surveys and interpretable machine learning-driven sarcopenia screening.Therapeutic advances in endocrinology and metabolism · 2026Article
- C-reactive protein-albumin-lymphocyte (CALLY) index as a novel inflammatory marker for sarcopenia: evidence from a cross-sectional study.Turkish journal of medical sciences · 2026Article
- Development and validation of a Four-Year predictive model for sarcopenia in older adults: insights from the CHARLS cohort.Aging clinical and experimental research · 2025Article
- Metabolic and Inflammatory Biomarkers Predicting Sarcopenic Obesity and Cardiometabolic Risk in Arab Women: A Cross-Sectional Study.International journal of molecular sciences · 2025Article
- Gliflozines as add-on to Arni in echocardiographic, sarcopenic and oxidative stress parameters in elderly patients with chronic heart failure.Aging clinical and experimental research · 2025Article
- Association of hematological parameters and inflammatory indices with sarcopenia in the United States and China: a cross-sectional study.European journal of medical research · 2025Article
- Multimodal data-driven prognostic model for predicting long-term outcomes in older adult patients with sarcopenia: a retrospective cohort study.Frontiers in public health · 2025Article
- Radiotherapy and inflammaging: the influence of prostate cancer radiotherapy on systemic inflammation.World journal of urology · 2024Article
- Higher CALLY index levels indicate lower sarcopenia risk among middle-aged and elderly community residents as well as hospitalized patients.Scientific reports · 2024Article
- The survival in octogenarians undergoing surgery for pancreatic cancer and its association with the nutritional status.Surgery today · 2024Article
- Osteosarcopenia is a significant predictor of recurrence and the prognosis after resection for extrahepatic bile duct cancer.Surgery today · 2024Article
- Sarcopenia accompanied by systemic inflammation can predict clinical outcomes in patients with head and neck cancer undergoing curative therapy.Frontiers in oncology · 2024Article
- Diagnostic Value of Nutritional Risk Index and Other Indices for Predicting Sarcopenia in the Middle-Aged and Elderly Population of China Without Cancer: A ROC Curve Analysis.International journal of general medicine · 2024Article
- Elderly-Onset Rheumatoid Arthritis: Characteristics and Treatment Options.Medicina (Kaunas, Lithuania) · 2023Review
- Prognostic significance of preoperative osteopenia on outcomes after gastrectomy for gastric cancer.Annals of gastroenterological surgery · 2023Article
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7 authors.
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Abstract
The platelet-to-lymphocyte ratio (PLR) has been extensively studied in oncologic diseases. However, the correlation between PLR and sarcopenia remains unknown. In this cross-sectional analysis, we enrolled 3,671 non-institutionalized individuals from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) aged ≥60 years and whose complete blood counts (CBCs), body composition measurements, and related demographic information was available. Skeletal muscle mass was assessed using a previously published equation (including age, sex, height, and bioelectrical impedance analysis). PLR values were estimated based on laboratory data. Multiple linear and logistic regression analyses, quartile-based stratified odds ratio comparisons, and trend tests were performed. Elevations in serum PLR values were significantly associated with sarcopenia status and negatively associated with skeletal muscle index. After additionally adjusting for other covariates, the significant negative correlation remained; moreover, participants with highest serum PLR values (≥155) had 2.36 times greater risk of sarcopenia than those with lowest PLR values (<90; odds ratio (OR) = 2.36; 95% confidence interval (CI): 1.21-3.31; p < 0.01). Higher PLR levels are associated with a greater risk of sarcopenia in geriatric populations. Thus, PLR as an inexpensive and easily measurable parameter can be considered as an inflammatory biomarker for sarcopenia.
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