ArticleMolecular pharmacology2018
Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA
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In one paragraph
Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- Comparison of the Conox (qCON) and Sedline (PSI) depth of anaesthesia indices to predict the hypnotic effect during desflurane general anaesthesia with ketamine.Journal of clinical monitoring and computing · 2021Trial
- Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia.bioRxiv : the preprint server for biology · 2026Article
- Neuro-Transcriptomic Responses to Polypharmacological Agents inBrain sciences · 2026Article
- Impact of General Anesthetics on Postoperative Infections-A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Impact of propofol on gastrointestinal cancer outcomes: A review of cellular behavior, growth, and metastasis.World journal of clinical oncology · 2025Review
- Mechanism of human α3β GlyR regulation by intracellular M3/M4 loop phosphorylation and 2,6-di-tert-butylphenol interaction.Nature communications · 2025Article
- Understanding paralogous epilepsy-associated GABAProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Acute Impact of Propofol on Blood-Brain Barrier Integrity in Mice.Pharmaceutical research · 2024Article
- Potentiation of the GABABiophysical journal · 2024Article
- Propofol Alleviates Anxiety-Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Effects of propofol on presynaptic synapsin phosphorylation in the mouse brain in vivo.Brain research · 2024Article
- Phenols and GABAFrontiers in pharmacology · 2024Review
- Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABABiomolecules · 2023Article
- Personalized Medicine for Classical Anesthesia Drugs and Cancer Progression.Journal of personalized medicine · 2022Review
- Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors.Anesthesiology · 2022Article
- Activation of the Rat α1β2ε GABABiomolecules · 2022Article
- Sevoflurane Induces Neurotoxicity in the Animal Model with Alzheimer's Disease Neuropathology via Modulating Glutamate Transporter and Neuronal Apoptosis.International journal of molecular sciences · 2022Article
- Propofol-induced Unresponsiveness Is Associated with a Brain Network Phase Transition.Anesthesiology · 2022Article
- Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively MediateMolecular pharmacology · 2021Article
- Neonatal administration of a subanaesthetic dose of JM-1232(-) in mice results in no behavioural deficits in adulthood.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Daniel J ShinDepartment of Anesthesiology (D.J.S., A.L.G., A.D.J., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (S.A.F.).
Allison L GermannDepartment of Anesthesiology (D.J.S., A.L.G., A.D.J., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (S.A.F.).
Alexander D JohnsonDepartment of Anesthesiology (D.J.S., A.L.G., A.D.J., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (S.A.F.).
Stuart A FormanDepartment of Anesthesiology (D.J.S., A.L.G., A.D.J., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (S.A.F.).
Joe Henry SteinbachDepartment of Anesthesiology (D.J.S., A.L.G., A.D.J., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (S.A.F.).
Gustav AkkDepartment of Anesthesiology (D.J.S., A.L.G., A.D.J., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (S.A.F.) akk@morpheus.wustl.edu.
Massachusetts General Hospital · USTaylor Family Institute for Innovative Psychiatric Research
Funding
General Anesthetic Sites in GABA-A Receptor Subunit Interfacial PocketsR01GM089745 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI FORMAN, STUART A · 2010 to 2020
$3.8MSYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4MNIGMS NIH HHS R01 GM089745NIGMS NIH HHS R01 GM108580
Abstract
GABA
Indexed as
Allosteric RegulationAnesthetics, IntravenousAnimalsBinding SitesDose-Response Relationship, DrugIon Channel GatingMutationPropofolReceptors, GABA-AXenopus laevisAnesthetics, IntravenousPropofolReceptors, GABA-A
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.