Evidence map›Paper›PMID 29192066›Full record

ArticlePhysiological reports2017

Epinephrine stimulates CXCL1 IL-1

Alex J Mattingly, Orlando Laitano, Thomas L Clanton

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Epinephrine stimulates CXCL1 IL-1Physiological reports · 2017
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alex J MattinglyDepartment of Applied Physiology & Kinesiology, University of Florida, College of Health and Human Performance, Gainesville, Florida.
Orlando LaitanoDepartment of Applied Physiology & Kinesiology, University of Florida, College of Health and Human Performance, Gainesville, Florida.
Thomas L ClantonDepartment of Applied Physiology & Kinesiology, University of Florida, College of Health and Human Performance, Gainesville, Florida.ORCID http://orcid.org/0000-0003-0600-7150
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Catecholamines stimulate interleukin-6 (IL-6) secretion in skeletal muscles. However, whether other cytokines are secreted is currently unknown. Skeletal muscle ex vivo preparations commonly used to study cytokine secretion have dealt with limitations including auto-oxidation of catecholamines. The use of metal chelators could be an alternative to avoid auto-oxidation and allow catecholamines to be used at physiological doses. We exposed isolated soleus muscles to 1 or 100 ng/mL epinephrine (EPI) and collected bath samples at 1 and 2 h for multiplex cytokine analysis. Keratinocyte chemoattractant (CXCL1), IL-6, and IL-1

Indexed as

AnimalsChemokine CXCL1DeferoxamineEpinephrineInterleukin-1alphaInterleukin-6MaleMiceMice, Inbred C57BLMuscle, SkeletalNorepinephrineChemokine CXCL1DeferoxamineEpinephrineInterleukin-1alphaInterleukin-6NorepinephrineDeferoxamineepinephrineIL‐1alphakeratinocyte chemoattractantmyokinestress

Identifiers

PMID29192066
PMCPMC5727277
OpenAlexW2773245255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.