ArticleScience (New York, N.Y.)2017
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06974097 (Tumor Associated Neutrophils as a Biomarker of Chemo-immunotherapy Response in Locally Advanced Non-small Cell Lung Cancer), which is not on this map. Cited by 252 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 1 pooled it
13.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tumor Associated Neutrophils as a Biomarker of Chemo-immunotherapy Response in Locally Advanced Non-small Cell Lung Cancer : a Model Based on Neoadjuvant Strategy
Who cites it
252 citing papers in PubMed, 1 synthesis or guideline pooled it, 369 citations in OpenAlex.
- Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.Circulation research · 2020Pooled it
- Innate [European journal of nuclear medicine and molecular imaging · 2025Trial
- Dynamic single-cell landscape reveals a T-cell-suppressed microenvironment and a conserved neutrophil program in the lung metastatic niche.Genes & diseases · 2026Article
- Disease-associated myeloid states in cardiac remodeling: A new era of cardiac inflammation research enabled by computational biology.The journal of physiological sciences : JPS · 2026Review
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- Automated three-dimensional radiomic body composition analysis enhances survival prediction in resectable non‑small cell lung cancer.European radiology experimental · 2026Article
- From Glycocode to Precision Oncology: Therapeutic Strategies Targeting Aberrant O-GalNAc Glycosylation in Cancer.Chemical reviews · 2026Review
- Higher osteocalcin levels are associated with preserved β-cell function in early-established type 1 diabetes.Journal of endocrinological investigation · 2026Article
- Cancer-associated alterations in O-GalNAc glycosylation.Glycobiology · 2026Review
- Tumor heterogeneity: development, mechanisms, and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.Cancer discovery · 2026Article
- SiglecF-expressing neutrophils differentiate from mature neutrophils locally in the heart after myocardial infarction.Experimental hematology · 2026Article
- A decreased postoperative basophil percentage is an independent risk factor for prognosis in patients with lung cancer.Journal of thoracic disease · 2026Article
- Article
- Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling.Journal of experimental & clinical cancer research : CR · 2026Article
- MurineCyto-Det: A High-Resolution Murine BALF Cytology Dataset for Leukocyte Segmentation and Detection.bioRxiv : the preprint server for biology · 2026Article
- Article
- Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma.EMBO molecular medicine · 2026Article
- Structural immunity: immune cells as architects of tissue barriers.Nature reviews. Immunology · 2026Review
- Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer.Molecular oncology · 2026Review
192 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 4 institutions in 3 countries.
Camilla EngblomCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Christina PfirschkeCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-9434-4485
Rapolas ZilionisDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9697-2431
Janaina Da Silva MartinsEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-8249-7011
Stijn A BosDepartment of Radiology, Massachusetts General Hospital, MA 02114, USA.
Gabriel CourtiesCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Steffen RickeltHoward Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-5224-7764
Nicolas SevereCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1971-337X
Ninib BaryawnoCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-8211-8368
Julien FagetSwiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.ORCID 0000-0003-0848-7135
Virginia SavovaDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
David ZemmourGraduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0990-217X
Jaclyn KlineCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-6897-5520
Marie SiwickiCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Christopher GarrisCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5764-6203
Ferdinando PucciCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-1300-9931
Hsin-Wei LiaoCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5905-2601
Yi-Jang LinCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-1850-4245
Andita NewtonCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-0180-9824
Omar K YaghiCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Benoit TricotCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Gregory R WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-3148-8411
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-4021-1887
Virna Cortez-RetamozoCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-3549-7390
Etienne MeylanSwiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Richard O HynesHoward Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-7603-8396
Marie DemayEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-5845-5479
Allon KleinDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8913-7879
Miriam A BredellaDepartment of Radiology, Massachusetts General Hospital, MA 02114, USA.
David T ScaddenCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-9821-7133
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-0828-4143
Mikael J PittetCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. mpittet@mgh.harvard.edu.ORCID 0000-0002-2060-4691
Harvard University · USMassachusetts General Hospital · USÉcole Polytechnique Fédérale de Lausanne · CHHoward Hughes Medical Institute · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MStatisticsP50CA086355 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAZITSCHEK, RALPH · 2000 to 2015
$27.8MUSING DIGITAL STORIES TO IMPROVE COLORECTAL CANCER SCREENING IN NATIVE AMERICANSP50CA148110 · NCI · UNIVERSITY OF WASHINGTON · PI GONZALES, ANGELA A · 2010 to 2014
$9.7MTumor-Stroma Interacions in the Tumor MicroenvironmentU54CA126515 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEINBERG, ROBERT A · 2006 to 2010
$6.5MIn vivo behavior of monocytes in resting and inflammatory conditionsR01AI084880 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL · 2011 to 2020
$4.4MThe Extracellular Matrix in Tumor Progression and MetastasisU54CA163109 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEINBERG, ROBERT A · 2011 to 2015
$3.7MSkeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5MImaging tumor associated macrophage (TAM) functionR01CA206890 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL, WEISSLEDER, MD, PHD, RALPH · 2017 to 2021
$1.9MDroplet microfluidic technology for single cell cancer genomicsR33CA212697 · NCI · HARVARD MEDICAL SCHOOL · PI KLEIN, ALLON MOSHE · 2017 to 2019
$1.3MHoward Hughes Medical InstituteNCI NIH HHS P50 CA086355NCI NIH HHS P50 CA148110NCI NIH HHS R01 CA206890NCI NIH HHS R33 CA212697NCI NIH HHS U54 CA126515NCI NIH HHS U54 CA163109NIAID NIH HHS R01 AI084880NIAMS NIH HHS P30 AR066261NIGMS NIH HHS T32 GM007753
Abstract
Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly understood. Here, we show in mice and cancer patients (
Indexed as
Neutrophil InfiltrationAdenocarcinomaAdenocarcinoma of LungAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBone and BonesBone DensityBone Marrow CellsCell Line, TumorHumansLectinsLung NeoplasmsMiceMice, Inbred C57BLMyeloid CellsAGER protein, humanAntigens, CDAntigens, Differentiation, MyelomonocyticLectinsOsteocalcinReceptor for Advanced Glycation End ProductsSIGLEC5 protein, human
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Read underepoch 390
Registered trials
NCT06974097ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.