ArticleProceedings of the National Academy of Sciences of the United States of America1989
Fourier analysis of cell motility: correlation of motility with metastatic potential.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 190 citations in OpenAlex.
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- Migration speed of captured breast cancer subpopulations correlates with metastatic fitness.Journal of cell science · 2023Article
- Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo.Scientific reports · 2022Article
- Multi-drug-resistance efflux in cisplatin-naive and cisplatin-exposed A2780 ovarian cancer cells responds differently to cell culture dimensionality.Molecular and clinical oncology · 2021Article
- Emerging machine learning approaches to phenotyping cellular motility and morphodynamics.Physical biology · 2021Review
- Between-tumor and within-tumor heterogeneity in invasive potential.PLoS computational biology · 2020Article
- Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo.Nature communications · 2018Article
- Simple Physical Model Unravels Influences of Chemokine on Shape Deformation and Migration of Human Hematopoietic Stem Cells.Scientific reports · 2018Article
- MiRNA-545 negatively regulates the oncogenic activity of EMS1 in gastric cancer.Cancer medicine · 2018Article
- A brief history of intracrine androgen metabolism by castration-recurrent prostate cancer.American journal of clinical and experimental urology · 2018Review
- Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance.PLoS computational biology · 2018Article
- Distinctive behaviour of live biopsy-derived carcinoma cells unveiled using coherence-controlled holographic microscopy.PloS one · 2017Article
- Improving fascin inhibitors to block tumor cell migration and metastasis.Molecular oncology · 2016Article
- Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy.Nature communications · 2015Article
- Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization.Nature communications · 2015Article
- Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells.Scientific reports · 2015Article
- Motility efficiency and spatiotemporal synchronization in non-metastatic vs. metastatic breast cancer cells.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Development and characterization of a reliable mouse model of colorectal cancer metastasis to the liver.Clinical & experimental metastasis · 2013Article
- Mouse models for tumor metastasis.Methods in molecular biology (Clifton, N.J.) · 2012Article
- p38γ promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.Cancer research · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We report the development of a computerized, mathematical system for quantitating the various types of cell motility. This Fourier analysis method simultaneously quantifies for individual cells (i) temporal changes in cell shape represented by cell ruffling, undulation, and pseudopodal extension, (ii) cell translation, and (iii) average cell size and shape. This spatial-temporal Fourier analysis was tested on a series of well-characterized animal tumor cell lines of rat prostatic cancer to study in a quantitative manner the correlation of cell motility with increasing in vivo metastatic potential. Fourier motility coefficients measuring pseudopodal extension correlated best with metastatic potential in the cell lines studied. This study demonstrated that Fourier analysis provides quantitative measurement of cell motility that may be applied to the study of biological processes. This analysis should aid in the study of the motility of individual cells in various areas of cellular and tumor biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.