Evidence map›Paper›PMID 29191172›Full record

ArticleBMC cancer2017

MicroRNA profile in HBV-induced infection and hepatocellular carcinoma.

Guanyu Wang, Fulu Dong, Zhiyao Xu, Sherven Sharma, Xiaotong Hu, Dafang Chen, Lumin Zhang, Jinping Zhang, Qinghua Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  10. Chronic PFOA exposure in vitro causes acquisition of multiple tumor cell characteristics in rat liver cells.Toxicology in vitro : an international journal published in association with BIBRA · 2023
    Article
  11. Review
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  14. Article
  15. CA10 is associated with HBV-related hepatocarcinogenesis.Biochemistry and biophysics reports · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Guanyu WangDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Fulu DongInstitutes of Biology and Medical Sciences, Soochow University, Soochow, Jiangsu, China.
Zhiyao XuKey Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Sherven SharmaDavid Geffen School of Medicine at UCLA, and the Department of Veterans Affairs, Los Angeles, CA, USA.
Xiaotong HuKey Laboratory of Biotherapy of Zhejiang Province, Hangzhou, Zhejiang, China.
Dafang ChenKey Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Lumin ZhangKey Laboratory of Biotherapy of Zhejiang Province, Hangzhou, Zhejiang, China.
Jinping ZhangInstitutes of Biology and Medical Sciences, Soochow University, Soochow, Jiangsu, China. j_pzhang@suda.edu.cn.
Qinghua DongKey Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. dongqinghua@zju.edu.cn.
Sir Run Run Shaw Hospital · CNSoochow University · CNMinistry of Education of the People's Republic of China · CNUniversity of California, Los Angeles · USZhejiang University · CN

Funding

National Natural Science Foundation of China 31270939, 81471526, 91442110National Natural Science Foundation of China 81272493National Natural Science Foundation of China 81300553National Natural Science Foundation of China 81472213Natural Science Foundation of Jiangsu Province BK2012617Science Technology Department of Zhejiang Province 2015C33134Science Technology Department of Zhejiang Province 2015C37112
6 · The paper itself

Abstract

backgroundMicroRNAs (miRNAs) exhibit essential regulatory functions related to cell growth, apoptosis, development and differentiation. Dysregulated expression of miRNAs is associated with a wide variety of human diseases. As such miRNA signatures are valuable as biomarkers for disease and for making treatment decisions. Hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC). Here we screened for miRNAs in chronic HBV associated HCC.

methodsTo determine the miRNAs in HCC occurrence associated with HBV infection, we analyzed global miRNA expression profiles in 12 pairs of HCC and adjacent matched non-HCC tissues from HBV-positive and HBV-negative patients using microarray analyses. The microarray result was validated by real-time PCR in 32 HBV-positive and 24 HBV-negative patient HCC samples. The potential candidate target genes of the miRNAs were predicted by miRWalk software. Genes simultaneously predicted as targets by two or more miRNAs were subjected to GO and KEGG pathway analysis. The miRNA regulatory network analysis was performed using the Ingenuity Pathway Analysis (IPA) software.

resultsEight miRNAs (miR-223, miR-98, miR-15b, miR-199a-5p, miR-19b, miR-22, miR-451, and miR-101) were involved in HBV-unrelated HCC, 5 miRNAs (miR-98, miR-375, miR-335, miR-199a-5p, and miR-22) were involved in HBV infection, and 7 miRNAs (miR-150, miR-342-3p, miR-663, miR-20b, miR-92a-3p, miR-376c-3p and miR-92b) were specifically altered in HBV-related HCC. Gene Ontology and KEGG analyses predict that these HBV-related HCC miRNAs are involved in the regulation of: transcription, RNA polymerase II promoter, phosphorylation of proteins through MAPK signaling pathway, focal adhesion, and actin cytoskeleton. IPA analysis also suggest that these miRNAs act on AGO2, TP53, CCND1, and 11 other genes that significantly influence HCC occurrence and HBV infection.

conclusionOur data indicates that the unique 7 miRNAs expression signature could be involved in the development HBV- related HCC.

Indexed as

Carcinoma, HepatocellularComputational BiologyGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHepatitis BHumansLiver NeoplasmsMicroRNAsOligonucleotide Array Sequence AnalysisSoftwareMicroRNAsHepatitis B virusHepatocellular carcinomamicroRNARegulatory network

Identifiers

PMID29191172
PMCPMC5709924
OpenAlexW2771300693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.