Evidence map›Paper›PMID 29191009›Full record

ArticleACS applied materials & interfaces2018

Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices.

Paulius Mikulskis, Andrew Hook, Adam A Dundas, Derek Irvine, Olutoba Sanni, Daniel Anderson, Robert Langer, Morgan R Alexander, Paul Williams, David A Winkler

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Mapping Biomaterial Complexity by Machine Learning.Tissue engineering. Part A · 2024
    Review
  3. Review
  4. Effect of DMPEI coating against biofilm formation on PVC catheter surface.World journal of microbiology & biotechnology · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Antimicrobial Properties of Plant Fibers.Molecules (Basel, Switzerland) · 2022
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Precision Design of Antimicrobial Surfaces.Frontiers in medical technology · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Sparse QSAR modelling methods for therapeutic and regenerative medicine.Journal of computer-aided molecular design · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Paulius MikulskisSchool of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
Andrew HookSchool of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
Adam A DundasSchool of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
Derek IrvineFaculty of Engineering, University of Nottingham , Nottingham NG7 2RD, United Kingdom.ORCID http://orcid.org/0000-0003-1461-9851
Olutoba SanniSchool of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
Daniel AndersonKoch Institute for Integrative Cancer Research, MIT , Cambridge, Massachusetts 02139-4307, United States.ORCID http://orcid.org/0000-0003-0151-4903
Robert LangerKoch Institute for Integrative Cancer Research, MIT , Cambridge, Massachusetts 02139-4307, United States.ORCID http://orcid.org/0000-0003-4255-0492
Morgan R AlexanderSchool of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
Paul WilliamsCentre for Biomolecular Sciences, School of Life Sciences, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
David A WinklerSchool of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.ORCID http://orcid.org/0000-0002-7301-6076
University of Nottingham · GBAllen Institute · US

Funding

Wellcome Trust 085245Wellcome Trust 103882Wellcome Trust 103884
6 · The paper itself

Abstract

Bacterial infections in healthcare settings are a frequent accompaniment to both routine procedures such as catheterization and surgical site interventions. Their impact is becoming even more marked as the numbers of medical devices that are used to manage chronic health conditions and improve quality of life increases. The resistance of pathogens to multiple antibiotics is also increasing, adding an additional layer of complexity to the problems of employing safe and effective medical procedures. One approach to reducing the rate of infections associated with implanted and indwelling medical devices is the use of polymers that resist the formation of bacterial biofilms. To significantly accelerate the discovery of such materials, we show how state of the art machine learning methods can generate quantitative predictions for the attachment of multiple pathogens to a large library of polymers in a single model for the first time. Such models facilitate design of polymers with very low pathogen attachment across different bacterial species that will be candidate materials for implantable or indwelling medical devices such as urinary catheters, cochlear implants, and pacemakers.

Indexed as

Biomedical ResearchAnti-Bacterial AgentsBiofilmsCoated Materials, BiocompatiblePolymersQuality of LifeAnti-Bacterial AgentsCoated Materials, BiocompatiblePolymersantimicrobial surfacesbroad spectrummachine learningmedical devicespolymer arrays

Identifiers

PMID29191009
PMCPMC7613461
OpenAlexW2772316334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.