Evidence map›Paper›PMID 29190989›Full record

ArticleOncotarget2017

Aberrant pattern of regional cerebral blood flow in Alzheimer's disease: a voxel-wise meta-analysis of arterial spin labeling MR imaging studies.

Hai Rong Ma, Ping Lei Pan, Li Qin Sheng, Zhen Yu Dai, Gen Di Wang, Rong Luo, Jia Hui Chen, Pei Rong Xiao, Jian Guo Zhong, Hai Cun Shi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  3. Can Beetroot (Nutrients · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hai Rong MaDepartment of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, PR China.
Ping Lei PanDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Li Qin ShengDepartment of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, PR China.
Zhen Yu DaiDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Gen Di WangDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Rong LuoDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Jia Hui ChenDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Pei Rong XiaoDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Jian Guo ZhongDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Hai Cun ShiDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Yancheng Third People's Hospital · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have applied arterial spin labeling (ASL) to characterize cerebral perfusion patterns of Alzheimer's disease (AD). However, findings across studies are not conclusive. A quantitatively voxel-wise meta-analysis to pool the resting-state ASL studies that measure regional cerebral blood flow (rCBF) alterations in AD was conducted to identify the most consistent and replicable perfusion pattern using seed-based d mapping. The meta-analysis, including 17 ASL studies encompassing 327 AD patients and 357 healthy controls, demonstrated that decreased rCBF in AD patients relative to healthy controls were consistently identified in the bilateral posterior cingulate cortices (PCC)/precuneus, bilateral inferior parietal lobules (IPLs), and left dorsolateral prefrontal cortex. The meta-regression analysis showed that more severe cognitive impairment in the AD samples correlated with greater decreases of rCBF in the bilateral PCC and left IPL. This study characterizes an aberrant ASL-rCBF perfusion pattern of AD involving the posterior default mode network and executive network, which are implicated in its pathophysiology and hold promise for developing imaging biomarkers.

Indexed as

Alzheimer’s diseasearterial spin labelingdefault mode networkmeta-analysisseed-based d mapping

Identifiers

PMID29190989
PMCPMC5696255
OpenAlexW2763023631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.