ArticleOncotarget2017
Dietary apple pectic oligosaccharide improves gut barrier function of rotavirus-challenged weaned pigs by increasing antioxidant capacity of enterocytes.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The promise of pectic oligosaccharides as a novel sustainable additive in poultry production: A systematic review.Poultry science · 2026Pooled it
- The Role and Potential Mechanism of Pectin and Pectin Oligosaccharides in Treating Intestinal Inflammation by Regulating Gut Microbiota.Probiotics and antimicrobial proteins · 2026Review
- Dietary supplementation with Bacillus-based probiotic improves gut health in the weaned piglets challenged by rotavirus.Journal of animal science and biotechnology · 2025Article
- Maternal or post-weaning dietary fructo-oligosaccharide supplementation reduces stillbirth rate of sows and diarrhea of weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets.Journal of animal science and biotechnology · 2024Review
- The Use of Fruit and Vegetable by-Products as Enhancers of Health Status of Piglets after Weaning: The Role of Bioactive Compounds from Apple and Carrot Industrial Wastes.Veterinary sciences · 2023Review
- Effect of Dietary Lactose Supplementation on Growth Performance and Intestinal Epithelium Functions in Weaned Pigs Challenged by Rotavirus.Animals : an open access journal from MDPI · 2022Article
- Mango Pectic Oligosaccharides: A Novel Prebiotic for Functional Food.Frontiers in nutrition · 2022Review
- Effects of Dietary L-Theanine on Growth Performance, Antioxidation, Meat Quality, and Intestinal Microflora in White Feather Broilers With Acute Oxidative Stress.Frontiers in veterinary science · 2022Article
- Dietary apple pectic oligosaccharide improves reproductive performance, antioxidant capacity, and ovary function of broiler breeders.Poultry science · 2021Article
- Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity.Journal of animal science and biotechnology · 2021Article
- The effect of dietary pectic oligosaccharide supplementation on intestinal health of broiler breeders with different egg-laying rates.Poultry science · 2021Article
- l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-κB Pathway in Rats.Frontiers in immunology · 2021Article
- Dietary pectic oligosaccharide supplementation improves rat reproductive performance via regulating intestinal volatile fatty acids during middle gestation.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Article
- The effects of prebiotics on growth performance and in vitro immune biomarkers in weaned pigs.Translational animal science · 2019Article
- Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Article
- l-Isoleucine Administration Alleviates Rotavirus Infection and Immune Response in the Weaned Piglet Model.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotavirus can lead to decreasing gut barrier function and diarrhea of children and young animals. Apple pectic oligosaccharide treatment reduced diarrhea in rotavirus-infected piglets. This study was conducted to explore whether apple pectic oligosaccharide administration could protect gut barrier function of piglets against rotavirus infection. A total of 28 crossbred weaned barrows were allotted into 2 treatments fed the diets supplementing 0 and 200 mg/kg apple pectic oligosaccharide. Half of pigs in each diet treatment were challenged by rotavirus on d 15. The whole duration of this experiment is 18 days. Rotavirus challenge increased average diarrhea index, and impaired microbiota in cecal digesta, and histology, expressions of tight-junction proteins, mucins and glucagon like peptide-2 concentrations, antioxidant capacity, endoplasmic reticulum stress, autophagy and apoptosis in jejunal mucosa of piglets. However, dietary apple pectic oligosaccharide supplementation relieved effects of rotavirus challenge on diarrhea, gut health, and antioxidant capacity, endoplasmic reticulum stress, autophagy and apoptosis of jejunal mucosa in piglets. These results suggest that apple pectic oligosaccharide administration can prevent diarrhea and damage of gut barrier function via improving antioxidant capacity that might reduce endoplasmic reticulum stress, autophagy and apoptosis of intestinal epithelial cells in rotavirus-infected piglets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.