Evidence map›Paper›PMID 29190748›Full record

Observational studyPloS one2017

Low hepatitis C antibody screening rates among an insured population of Tennessean Baby Boomers.

James G Carlucci, Syeda A Farooq, Lindsey Sizemore, Michael Rickles, Brandon Cosley, Leigh McCormack, Carolyn Wester

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Economically Efficient Hepatitis C Virus Treatment Prioritization Improves Health Outcomes.Medical decision making : an international journal of the Society for Medical Decision Making · 2018
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

James G CarlucciVanderbilt University Medical Center, Nashville, Tennessee, United States of America.ORCID http://orcid.org/0000-0002-3969-8544
Syeda A FarooqVanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Lindsey SizemoreTennessee Department of Health, Nashville, Tennessee, United States of America.
Michael RicklesTennessee Department of Health, Nashville, Tennessee, United States of America.
Brandon CosleyCollaborating Health Insurer, Chattanooga, Tennessee, United States of America.
Leigh McCormackCollaborating Health Insurer, Chattanooga, Tennessee, United States of America.
Carolyn WesterTennessee Department of Health, Nashville, Tennessee, United States of America.
Tennessee Department of Health · USVanderbilt University Medical Center · US

Funding

Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Carolyn Audet · 2015 to 2026
$27.5M
Conducting Child Health Care Research in Vulnerable PopulationsT32HD060554 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARKIN, SHARI, WILLIAMS, DEREK J. · 2009 to 2019
$3.8M
NIAID NIH HHS P30 AI110527NICHD NIH HHS T32 HD060554
6 · The paper itself

Abstract

introductionChronic Hepatitis C Virus (HCV) infection is common and can cause liver disease and death. Persons born from 1945 through 1965 ("Baby Boomers") have relatively high prevalence of chronic HCV infection, prompting recommendations that all Baby Boomers be screened for HCV. If chronic HCV is confirmed, evaluation for antiviral treatment should be performed. Direct-acting antivirals can cure more than 90% of people with chronic HCV. This sequence of services can be referred to as the HCV "cascade of cure" (CoC). The Tennessee (TN) Department of Health (TDH) and a health insurer with presence in TN aimed to determine the proportion of Baby Boomers who access HCV screening services and appropriately navigate the HCV CoC in TN.

methodsTDH surveillance data and insurance claim records were queried to identify the cohort of Baby Boomers eligible for HCV testing. Billing codes and pharmacy records from 2013 through 2015 were used to determine whether HCV screening and other HCV-related services were provided. The proportion of individuals accessing HCV screening and other steps along the HCV CoC was determined. Multivariable analyses were performed to identify factors associated with HCV screening and treatment.

resultsAmong 501,388 insured Tennessean Baby Boomers, 7% were screened for HCV. Of the 40,019 who received any HCV-related service, 86% were screened with an HCV antibody test, 20% had a confirmatory HCV PCR, 9% were evaluated for treatment, and 4% were prescribed antivirals. Hispanics were more likely to be screened and treated for HCV than non-Hispanic whites. HCV screening was more likely to occur in the Nashville-Davidson region than in other regions of TN, but there were regional variations in HCV treatment.

conclusionsMany insured Tennessean Baby Boomers do not access HCV screening services, despite national recommendations. Demographic and regional differences in uptake along the HCV CoC should inform public health interventions aimed at mitigating the effects of chronic HCV.

Indexed as

Insurance CoverageInsurance, HealthAntibodies, ViralFemaleHepacivirusHepatitis C, ChronicHumansMaleMiddle AgedPolymerase Chain ReactionProspective StudiesTennesseeAntibodies, Viral

Identifiers

PMID29190748
PMCPMC5708755
OpenAlexW2771500685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.