ArticlePloS one2017
Investigating the validity of the DN4 in a consecutive population of patients with chronic pain.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04946149 (Psychosocial Factors, Lifestyle and Central Pain Processing as Potential Predictors of Outcome After Rehabilitation for Rotator Cuff Repair), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychosocial Factors, Lifestyle and Central Pain Processing as Potential Predictors of Outcome After Rehabilitation for Rotator Cuff Repair: A Study Design for a Prospective Longitudinal Cohort Study
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Diagnostic utility of patient history, clinical examination and screening tool data to identify neuropathic pain in low back related leg pain: a systematic review and narrative synthesis.BMC musculoskeletal disorders · 2020Pooled it
- Initial researches on neuro-functional status and evolution in chronic ethanol consumers with recent traumatic spinal cord injury.Journal of medicine and lifePooled it
- Methadone versus other opioids for refractory malignant bone pain: a pilot randomised controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Targeting the posterior thalamic hub: hemispheric-specific encoding of pain-depression comorbidity after hemorrhagic stroke.BMC medicine · 2026Article
- Development of a High-Sensitivity Screening Tool for Neuropathic Pain Integrating PainDETECT and BS-POP Using Machine Learning.Journal of pain research · 2026Article
- Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis.Scientific reports · 2025Article
- Overall Health Status of Patients with Mild-to-Moderate Cubital Tunnel Syndrome: A Case-Control Study.Healthcare (Basel, Switzerland) · 2025Article
- Association of depression and hydroxyurea use with neuropathic pain in hemoglobinopathies.Scientific reports · 2025Article
- Effectiveness of Vitamin B1-6-12 Supplementation Compared With Vitamin B12 and Gabapentin in Patients With Diabetic Peripheral Neuropathy.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Neuropathic pain appears to be the main symptom associated with higher disease burden and lower pain alleviation in degenerative lumbar disease fusion patients.Brain & spine · 2025Article
- The prevalence of neuropathic pain pathophysiology associated with ankle fracture: A study protocol.PloS one · 2025Article
- Usefulness of the DN4, S-LANSS, and painDETECT screening questionnaires to detect the neuropathic pain components in people with acute whiplash-associated disorders: a cross-sectional study.Pain medicine (Malden, Mass.) · 2024Article
- Donor-Site Morbidity Analysis of Thenar and Hypothenar Flap.Archives of plastic surgery · 2024Article
- Review
- Shedding light on neuropathic pain: Current and emerging tools for diagnosis, screening, and quantification.SAGE open medicine · 2024Review
- Evaluation of Neuropathic Pain after Total Knee Arthroplasty: Do Yellow Flags Matter?Journal of clinical medicine · 2023Article
- Chronic pain among Lebanese individuals with spinal cord injury: Pain interference and impact on quality of life.Current journal of neurology · 2023Article
- Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study.BMC palliative care · 2023Article
- Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options.International journal of molecular sciences · 2023Review
- Factors correlated with neuropathic pain among industrial workers in Vietnam: a multi-site cross-sectional study.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain is clinically described as pain caused by a lesion or disease of the somatosensory nervous system. The aim of this study was to assess the validity of the Dutch version of the DN4, in a cross-sectional multicentre design, as a screening tool for detecting a neuropathic pain component in a large consecutive, not pre-stratified on basis of the target outcome, population of patients with chronic pain. Patients' pain was classified by two independent (pain-)physicians as the gold standard. The analysis was initially performed on the outcomes of those patients (n = 228 out of 291) in whom both physicians agreed in their pain classification. Compared to the gold standard the DN4 had a sensitivity of 75% and specificity of 76%. The DN4-symptoms (seven interview items) solely resulted in a sensitivity of 70% and a specificity of 67%. For the DN4-signs (three examination items) it was respectively 75% and 75%. In conclusion, because it seems that the DN4 helps to identify a neuropathic pain component in a consecutive population of patients with chronic pain in a moderate way, a comprehensive (physical-) examination by the physician is still obligate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.