Evidence map›Paper›PMID 29190684›Full record

ArticlePloS one2017

Respiratory syncytial and influenza viruses in children under 2 years old with severe acute respiratory infection (SARI) in Maputo, 2015.

Mirela Pale, Afonso Nacoto, Almiro Tivane, Neuza Nguenha, Loira Machalele, Félix Gundane, Délcio Muteto, Josina Chilundo, Sandra Mavale, Cynthia Semá-Baltazar and 4 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 5 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Mirela PaleDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.ORCID http://orcid.org/0000-0003-3381-6914
Afonso NacotoDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Almiro TivaneDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Neuza NguenhaDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Loira MachaleleDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Félix GundaneDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Délcio MutetoDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Josina ChilundoPediatric Departments, Maputo Central Hospital, Maputo, Mozambique.
Sandra MavalePediatric Departments, Maputo Central Hospital, Maputo, Mozambique.
Cynthia Semá-BaltazarDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Germano PiresDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Orvalho AugustoDepartment of Microbiology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Tufária MussáDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Eduardo GudoDepartment of Technologic Platforms, National Institute of Health, Ministry of Health, Maputo, Mozambique.
Ministry of Health · MZEduardo Mondlane University · MZMaputo Central Hospital · MZ

Funding

NCIRD CDC HHS U51 IP000825
6 · The paper itself

Abstract

introductionAlthough respiratory syncytial virus (RSV) and influenza virus (influenza) infections are one of the leading causes of Severe Acute Respiratory Infections (SARI) and death in young children worldwide, little is known about the burden of these pathogens in Mozambique. MATERIAL AND

methodsFrom January 2015 to January 2016, nasopharyngeal swabs from 450 children, aged ≤2 years, who had been admitted to the Pediatric Department of the Maputo Central Hospital (HCM) in Mozambique, suffering with SARI were enrolled and tested for influenza and RSV using a real-time PCR assay.

resultsInfluenza and RSV were detected in 2.4% (11/450) and 26.7% (113/424) of the participants. Children with influenza were slightly older than those infected with RSV (10 months in influenza-infected children compared to 3 months in RSV-infected children); male children were predominant in both groups (63.6% versus 54.9% in children with influenza and RSV, respectively). There was a trend towards a higher frequency of influenza (72.7%) and RSV (93.8%) cases in the dry season. Bronchopneumonia, bronchitis and respiratory distress were the most common diagnoses at admission. Antibiotics were administered to 27,3% and 15,9% of the children with influenza and RSV, respectively. Two children, of whom, one was positive for RSV (aged 6 months) and another was positive for Influenza (aged 3 months) died; both were children of HIV seropositive mothers and had bronchopneumonia.

conclusionsOur data demonstrated that RSV, and less frequently influenza, occurs in children with SARI in urban/sub-urban settings from southern Mozambique. The occurrence of deaths in small children suspected of being HIV-infected, suggests that particular attention should be given to this vulnerable population. Our data also provide evidence of antibiotics prescription in children with respiratory viral infection, which represents an important public health problem and calls for urgent interventions.

Indexed as

Child, PreschoolFemaleHumansInfantInfant, NewbornInfluenza, HumanMaleMozambiqueOrthomyxoviridaePopulation SurveillanceReal-Time Polymerase Chain ReactionRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus Infections

Identifiers

PMID29190684
PMCPMC5708764
OpenAlexW2772367294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.