ArticleBrain : a journal of neurology2018
A human prefrontal-subthalamic circuit for cognitive control.
Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease
Mid-frontal Delta/Theta and Cognitive Control
Who cites it
77 citing papers in PubMed, 147 citations in OpenAlex.
- Low-Frequency Deep Brain Stimulation in Non-Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Behavioral changes preceded by subthalamic nucleus activity alterations in a progressive macaque model of Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Nonmotor Symptoms in Parkinson's Disease: Neurophysiology Biomarkers and Neuromodulation Approaches.Stereotactic and functional neurosurgery · 2026Review
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Correlation Between Electrode Location and Clinical Efficacy of Deep Brain Stimulation of the Subthalamic Nucleus in Isolated Generalized Dystonia.Journal of clinical medicine · 2026Article
- Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.Translational psychiatry · 2026Review
- Effects of Different STN-DBS Programming Strategies on Non-Motor Symptoms in Parkinson's Disease: A Retrospective Controlled Study.Journal of multidisciplinary healthcare · 2026Article
- Predicting Parkinson's disease and its progression based on radiomics in T1-weight images and α‑synuclein in cerebrospinal fluid.NPJ Parkinson's disease · 2025Article
- Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Theta-frequency subthalamic stimulation enhances conflict resolution in Parkinson's disease patients with freezing of gait through frontal cortex modulation.NPJ Parkinson's disease · 2025Article
- Precisely-timed outpatient recordings of subcortical local field potentials from wireless streaming-capable deep-brain stimulators: a method and toolbox.Journal of neuroscience methods · 2025Article
- Could adaptive deep brain stimulation treat freezing of gait in Parkinson's disease?Journal of neurology · 2025Review
- Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease.Neuroimage. Reports · 2025Article
- 20 Hz beta stimulation of the subthalamic nucleus improves response inhibition in Parkinson's disease.Brain communications · 2025Article
- Article
- Optimal level of human intracranial theta activity for behavioral switching in the subthalamo-medio-prefrontal circuit.Nature communications · 2024Article
- Cognition falters at ~4 Hz in Parkinson's disease.Trends in cognitive sciences · 2024Article
- Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys.Frontiers in neuroscience · 2024Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Neural mechanisms of domain-general inhibitory control.Trends in cognitive sciences · 2023Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The subthalamic nucleus is a key site controlling motor function in humans. Deep brain stimulation of the subthalamic nucleus can improve movements in patients with Parkinson's disease; however, for unclear reasons, it can also have cognitive effects. Here, we show that the human subthalamic nucleus is monosynaptically connected with cognitive brain areas such as the prefrontal cortex. Single neurons and field potentials in the subthalamic nucleus are modulated during cognitive processing and are coherent with 4-Hz oscillations in medial prefrontal cortex. These data predict that low-frequency deep brain stimulation may alleviate cognitive deficits in Parkinson's disease patients. In line with this idea, we found that novel 4-Hz deep brain stimulation of the subthalamic nucleus improved cognitive performance. These data support a role for the human hyperdirect pathway in cognitive control, which could have relevance for brain-stimulation therapies aimed at cognitive symptoms of human brain disease.awx300media15660002226001.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.