ArticleCerebral cortex (New York, N.Y. : 1991)2019
Human Cortical Thickness Organized into Genetically-determined Communities across Spatial Resolutions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Benchmarking overlapping community detection methods for applications in human connectomics.Network neuroscience (Cambridge, Mass.) · 2026Article
- Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation.NeuroImage · 2024Article
- Article
- Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.Nature communications · 2022Article
- Imaging Transcriptomics of Brain Disorders.Biological psychiatry global open science · 2022Review
- Dignity neuroscience: universal rights are rooted in human brain science.Annals of the New York Academy of Sciences · 2021Review
- Genome-wide haplotype association study in imaging genetics using whole-brain sulcal openings of 16,304 UK Biobank subjects.European journal of human genetics : EJHG · 2021Article
- Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness.Science advances · 2020Article
- Altered Sex Chromosome Dosage Induces Coordinated Shifts in Cortical Anatomy and Anatomical Covariance.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Imaging local genetic influences on cortical folding.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems.Nature communications · 2020Article
- On testing for spatial correspondence between maps of human brain structure and function.NeuroImage · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The cerebral cortex may be organized into anatomical genetic modules, communities of brain regions with shared genetic influences via pleiotropy. Such modules could represent novel phenotypes amenable to large-scale gene discovery. This modular structure was investigated with network analysis of in vivo MRI of extended pedigrees, revealing a "multiscale" structure where smaller and larger modules exist simultaneously and in partially overlapping fashion across spatial scales, in contrast to prior work suggesting a specific number of cortical thickness modules. Inter-regional genetic correlations, gene co-expression patterns and computational models indicate that two simple organizational principles account for a large proportion of the apparent complexity in the network of genetic correlations. First, regions are strongly genetically correlated with their homologs in the opposite cerebral hemisphere. Second, regions are strongly genetically correlated with nearby regions in the same hemisphere, with an initial steep decrease in genetic correlation with anatomical distance, followed by a more gradual decline. Understanding underlying organizational principles of genetic influence is a critical step towards a mechanistic model of how specific genes influence brain anatomy and mediate neuropsychiatric risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.