ArticleCerebral cortex (New York, N.Y. : 1991)2019
Major Feedforward Thalamic Input Into Layer 4C of Primary Visual Cortex in Primate.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The contribution of the koniocellular visual pathway to aversive learning in human visual cortex.Journal of neurophysiology · 2026Article
- Neuronal composition of processing modules in human V1: laminar density for neuronal and non-neuronal populations and a comparison with macaque.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice.Cell reports · 2023Article
- A Scientific Approach to Conscious Experience, Introspection, and Unconscious Processing: Vision and Blindsight.Brain sciences · 2022Review
- A Computational Model of Direction Selectivity in Macaque V1 Cortex Based on Dynamic Differences between On and Off Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A theory of direction selectivity for macaque primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.Annual review of neuroscience · 2021Review
- Anatomy and Physiology of Macaque Visual Cortical Areas V1, V2, and V5/MT: Bases for Biologically Realistic Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Review
- Densities and Laminar Distributions of Kv3.1b-, PV-, GABA-, and SMI-32-Immunoreactive Neurons in Macaque Area V1.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
One of the underlying principles of how mammalian circuits are constructed is the relative influence of feedforward to recurrent synaptic drive. It has been dogma in sensory systems that the thalamic feedforward input is relatively weak and that there is a large amplification of the input signal by recurrent feedback. Here we show that in trichromatic primates there is a major feedforward input to layer 4C of primary visual cortex. Using a combination of 3D-electron-microscopy and 3D-confocal imaging of thalamic boutons we found that the average feedforward contribution was about 20% of the total excitatory input in the parvocellular (P) pathway, about 3 times the currently accepted values for primates. In the magnocellular (M) pathway it was around 15%, nearly twice the currently accepted values. New methods showed the total synaptic and cell densities were as much as 150% of currently accepted values. The new estimates of contributions of feedforward synaptic inputs into visual cortex call for a major revision of the design of the canonical cortical circuit.
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