Evidence map›Paper›PMID 29190026›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Biolistic Labeling of Retinal Ganglion Cells.

Luca Della Santina, Yvonne Ou

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Luca Della SantinaDepartment of Ophthalmology, University of California, San Francisco, 10 Koret Way, San Francisco, CA, 94143, USA. luca.dellasantina@ucsf.edu.
Yvonne OuDepartment of Ophthalmology, University of California, San Francisco, 10 Koret Way, San Francisco, CA, 94143, USA.
University of California, San Francisco · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
Neuronal plasticity in glaucomaR01EY028148 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OU, YVONNE · 2018 to 2022
$2.2M
Compartmentalized neurodegeneration of retinal ganglion cells in glaucomaK08EY022676 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OU, YVONNE · 2012 to 2016
$1.1M
NEI NIH HHS K08 EY022676NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY028148
6 · The paper itself

Abstract

Labeling of cellular structures is of fundamental importance in the investigation of diseases of the central nervous system. Biolistic labeling of retinal ganglion cells (RGCs) allows visualization of dendritic and synaptic structures of RGCs in retinal explants from animal models of experimental glaucoma. This technique sparsely labels RGCs, and, due to the stochastic nature of the particle delivery, all RGC types can be potentially observed in the labeled tissue. Quantification of dendritic and synaptic properties permits examination of the specific alterations to RGC morphology at different stages of degeneration, such as dendritic shrinkage and excitatory synapse loss.

Indexed as

AnimalsBiolisticsDendritesDisease Models, AnimalGlaucomaMiceRetinal Ganglion CellsSynapsesBiolistic labelingDegenerationDendritesExcitatory synapsesGlaucomaPSD95Retinal ganglion cells

Identifiers

PMID29190026
PMCPMC8724011
OpenAlexW2774664987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.