Evidence map›Paper›PMID 29189988›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2018

Predictors of self-reported health-related quality of life according to the EQ-5D-Y in chronically ill children and adolescents with asthma, diabetes, and juvenile arthritis: longitudinal results.

Christiane Otto, Dana Barthel, Fionna Klasen, Sandra Nolte, Matthias Rose, Ann-Katrin Meyrose, Marcus Klein, Ute Thyen, Ulrike Ravens-Sieberer

Registry-linked trialAbstract read
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In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04169828 (The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04169828 nacompletednot on this mapstarted 2019, after this paper: background citation

The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis

TypeinterventionalSponsorUniversity of British ColumbiaRan2019 to 2025Enrolled52ConditionsJuvenile Idiopathic ArthritisArmsMethotrexate, Ondansetron, Folic/folinic acid
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Understanding Canadian stakeholders' views on measuring and valuing health for children and adolescents: a qualitative study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christiane OttoDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Research Unit Child Public Health, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52 (W29), 20246, Hamburg, Germany. c.otto@uke.de.ORCID 0000-0003-4197-8606
Dana BarthelDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Research Unit Child Public Health, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52 (W29), 20246, Hamburg, Germany.
Fionna KlasenDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Research Unit Child Public Health, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52 (W29), 20246, Hamburg, Germany.
Sandra NolteDepartment of Psychosomatic Medicine, Center of Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Matthias RoseDepartment of Psychosomatic Medicine, Center of Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Ann-Katrin MeyroseDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Research Unit Child Public Health, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52 (W29), 20246, Hamburg, Germany.
Marcus KleinDepartment of Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany.
Ute ThyenHospital for Pediatrics and Adolescent Medicine, University of Lübeck, Lübeck, Germany.
Ulrike Ravens-SiebererDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Research Unit Child Public Health, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52 (W29), 20246, Hamburg, Germany.

Funding

EuroQol Research Foundation (NL) EQ Project 2016270German Federal Ministry of Education and Research grant no. 0010-01GY1111
6 · The paper itself

Abstract

purposeHealth-related quality of life (HRQoL) is an important patient-reported outcome in clinical and health research. The EQ-5D-Y assesses child and adolescent HRQoL by five items on mobility, self-care, usual activities, pain/discomfort, and anxiety/depression as well as a visual analogue scale (VAS) on the current health state. This study investigates predictors of self-reported HRQoL according to the EQ-5D-Y in chronically ill children and adolescents using longitudinal data.

methodsData from the German Kids-CAT study on children and adolescents with asthma, diabetes, and juvenile arthritis gathered over a period of six months were analyzed (n = 310; 7-17 years old; 48% female). Self-, parent-, and pediatrician-reported data were collected from June 2013 to October 2014. Generalized linear mixed models and linear mixed models served to examine effects of socio-demographic as well as disease- and health-specific predictors on the items as well as on the VAS of the EQ-5D-Y.

resultsCeiling effects for the EQ-5D-Y indicated low burden of disease in the analyzed sample. Longitudinal analyses revealed associations between less health complaints and better HRQoL for all investigated HRQoL domains. Further, age- and gender-specific effects, and associations of better disease control, longer duration of the disease and less mental health problems with better HRQoL were found.

conclusionsSubjective health complaints and mental health problems should be considered in the care of children and adolescents with asthma, diabetes, and juvenile arthritis. Future research should suggest administering the items of the EQ-5D-Y with five instead of three response options, and investigate HRQoL over a longer period.

Indexed as

Patient Reported Outcome MeasuresAdolescentArthritis, JuvenileAsthmaChildDiabetes MellitusFemaleHumansLongitudinal StudiesMaleQuality of LifeSelf ReportSurveys and QuestionnairesAdolescentsChildrenChronic illnessEQ-5D-YQuality of life

Identifiers

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.