ArticleMolecular and cellular biochemistry2018
The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction.
Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Oleocanthal Protects C2C12 Myotubes against the Pro-Catabolic and Anti-Myogenic Action of Stimuli Able to Induce Muscle WastingNutrients · 2024Article
- DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting.Journal of cachexia, sarcopenia and muscle · 2024Article
- Dietary Cinnamaldehyde Enhances Growth Performance, Digestion, Immunity, and Lipid Metabolism in Juvenile Fat Greenling (Aquaculture nutrition · 2022Article
- Grape Extract Promoted α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells, Which Was Inverse to Resveratrol.Molecules (Basel, Switzerland) · 2021Article
- Polyphenols and Their Effects on Muscle Atrophy and Muscle Health.Molecules (Basel, Switzerland) · 2021Review
- CaOxidative medicine and cellular longevity · 2021Article
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- Synthesis and Biological Evaluation of HalogenatedMolecules (Basel, Switzerland) · 2020Article
- SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice.BMJ open gastroenterology · 2020Article
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- Pterostilbene Enhances Endurance Capacity via Promoting Skeletal Muscle Adaptations to Exercise Training in Rats.Molecules (Basel, Switzerland) · 2020Article
- Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.American journal of physiology. Cell physiology · 2019Article
- Giving combined medium-chain fatty acids and glucose protects against cancer-associated skeletal muscle atrophy.Cancer science · 2019Article
- The role of SIRT1 in skeletal muscle function and repair of older mice.Journal of cachexia, sarcopenia and muscle · 2019Article
- Article
- Expression of circular RNAs during C2C12 myoblast differentiation and prediction of coding potential based on the number of open reading frames and N6-methyladenosine motifs.Cell cycle (Georgetown, Tex.) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose restriction (GR) impairs muscle cell differentiation and evokes myotube atrophy. Resveratrol treatment in skeletal muscle cells improves inflammatory-induced reductions in skeletal muscle cell differentiation. We therefore hypothesised that resveratrol treatment would improve muscle cell differentiation and myotube hypertrophy in differentiating C2C12 myoblasts and mature myotubes during GR. Glucose restriction at 0.6 g/L (3.3 mM) blocked differentiation and myotube hypertrophy versus high-glucose (4.5 g/L or 25 mM) differentiation media (DM) conditions universally used for myoblast culture. Resveratrol (10 µM) treatment increased SIRT1 phosphorylation in DM conditions, yet did not improve differentiation when administered to differentiating myoblasts in GR conditions. Resveratrol did evoke increases in hypertrophy of mature myotubes under DM conditions with corresponding elevated Igf-I and Myhc7 gene expression, coding for the 'slow' type I MYHC protein isoform. Inhibition of SIRT1 via EX-527 administration (100 nM) also reduced myotube diameter and area in DM conditions and resulted in lower gene expression of Myhc 1, 2 and 4 coding for 'intermediate' and 'faster' IIx, IIa and IIb protein isoforms, respectively. Resveratrol treatment did not appear to modulate phosphorylation of energy-sensing protein AMPK or protein translation initiator P70S6K. Importantly, in mature myotubes, resveratrol treatment was able to ameliorate reduced myotube growth in GR conditions over an acute 24-h period, but not over 48-72 h. Overall, resveratrol evoked myotube hypertrophy in DM conditions while favouring 'slower' Myhc gene expression and acutely ameliorated impaired myotube growth observed during glucose restriction.
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