Evidence map›Paper›PMID 29189894›Full record

ReviewCurrent genetics2018

The importance of an interaction network for proper DNA polymerase ζ heterotetramer activity.

Ewa Szwajczak, Iwona J Fijalkowska, Catherine Suski

Abstract readReview
In one paragraph

Review in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
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  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ewa SzwajczakInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106, Warszawa, Poland.
Iwona J FijalkowskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106, Warszawa, Poland.
Catherine SuskiInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106, Warszawa, Poland. suski.c@ibb.waw.pl.ORCID http://orcid.org/0000-0002-4892-6633

Funding

Fundacja na rzecz Nauki Polskiej PARENT/BRIDGE/2013-7/13National Science Center, Poland B/ZN1/02773
6 · The paper itself

Abstract

Precisely controlled mechanisms have been evolved to rescue impeded DNA replication resulting from encountered obstacles and involve a set of low-fidelity translesion synthesis (TLS) DNA polymerases. Studies in recent years have brought new insights into those TLS polymerases, especially concerning the structure and subunit composition of DNA polymerase zeta (Pol ζ). Pol ζ is predominantly involved in induced mutagenesis as well as the bypass of noncanonical DNA structures, and it is proficient in extending from terminal mismatched nucleotides incorporated by major replicative DNA polymerases. Two active forms of Pol ζ, heterodimeric (Pol ζ

Indexed as

Protein Interaction MapsBiopolymersDNA-Directed DNA PolymeraseMutagenesisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBiopolymersDNA-Directed DNA PolymeraseDNA polymerase zetaSaccharomyces cerevisiae ProteinsCysB motifDNA polymerase zeta (Pol ζ)MutagenesisSaccharomyces cerevisiaeTranslesion synthesis

Identifiers

PMID29189894
PMCPMC5948306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.