ArticleJournal of molecular evolution2018
On the Early Evolution of Catabolic Pathways: A Comparative Genomics Approach. I. The Cases of Glucose, Ribose, and the Nucleobases Catabolic Routes.
Article in Journal of molecular evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- The Road so Far: Tracing the Molecular Evolution of Hexokinase Family in Metazoa.Genome biology and evolution · 2026Article
- Revisiting the Glucose Kinase Superfamily: From Origins to the Evolution of Metabolism.Genome biology and evolution · 2025Article
- Ancestry of RNA/RNA interaction regions within segmented ribosomes.RNA (New York, N.Y.) · 2023Article
- Protometabolic Reduction of NADJACS Au · 2021Article
- An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life.The Biochemical journal · 2018Review
- Primitive Dark-Phase Cycle of Photosynthesis at the Origin of Life.Journal of molecular evolution · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Compared with the large corpus of published work devoted to the study of the origin and early development of anabolism, little attention has been given to the discussion of the early evolution of catabolism in spite of its significance. In the present study, we have used comparative genomics to explore the evolution and phylogenetic distribution of the enzymes that catalyze the extant catabolic pathways of the monosaccharides glucose and ribose, as well as those of the nucleobases adenine, guanine, cytosine, uracil, and thymine. Based on the oxygen dependence of the enzymes, their conservation, and evolution, we speculate on the relative antiquity of the pathways. Our results allow us to suggest which catabolic pathways and enzymes may have already been present in the last common ancestor. We conclude that the enzymatic degradations of ribose, as well as those of purines adenine and guanine, are among the most ancient catabolic pathways which can be traced by protein-based methodologies.
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