Evidence map›Paper›PMID 29189834›Full record

ArticleChemical communications (Cambridge, England)2017

In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.

Philip A Storm, Craig A Townsend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Thioesterase enzyme families: Functions, structures, and mechanisms.Protein science : a publication of the Protein Society · 2022
    Article
  2. Core Steps to the Azaphilone Family of Fungal Natural Products.Chembiochem : a European journal of chemical biology · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Philip A StormDepartment of Chemistry, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA. ctownsend@jhu.edu.
Craig A Townsend

Funding

Iterative Polyketide Synthase Function, Structure and PathwaysR01ES001670 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 1985 to 2023
$9.2M
The Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5M
NIEHS NIH HHS R01 ES001670NIGMS NIH HHS T32 GM080189
6 · The paper itself

Abstract

Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.

Indexed as

Acyl Carrier ProteinCitrininFungal ProteinsHydrolasesHydrolysisIsomerismMonascusMutagenesis, Site-DirectedPolyketide SynthasesAcyl Carrier ProteinCitrininFungal ProteinsHydrolasesPolyketide Synthases

Identifiers

PMID29189834
PMCPMC5822715

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.