ArticleThe Pediatric infectious disease journal2018
Invasive Haemophilus influenzae Serotype a Infection in Children: Clinical Description of an Emerging Pathogen-Alaska, 2002-2014.
Article in The Pediatric infectious disease journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.
- Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Fatal inflammation: understanding meningitis mortality in the United States (1999-2020).BMC neurology · 2026Observational
- Clinical Course and Outcomes of Invasive Haemophilus influenzae Infections among Children at Two Hospitals in Alaska.The Journal of pediatrics · 2026Article
- Haemophilus influenzae serotype a meningitis in an elderly patient: A case report and literature review.IDCases · 2024Article
- Report ofPediatric investigation · 2023Article
- Epidemiology of invasiveInternational journal of circumpolar health · 2022Article
- Phylogenetic Structure and Comparative Genomics of Multi-National InvasiveFrontiers in microbiology · 2022Article
- Racial Disparities in Invasive Haemophilus influenzae Disease-United States, 2008-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Increased Incidence of Invasive Haemophilus influenzae Disease Driven by Non-Type B Isolates in Ontario, Canada, 2014 to 2018.Microbiology spectrum · 2021Article
- Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use.Clinical microbiology reviews · 2021Review
- Clinical and Molecular Epidemiology of Invasive Haemophilus influenzae Serotype a Infections in Utah Children.Journal of the Pediatric Infectious Diseases Society · 2020Article
- Current Epidemiology and Trends in Invasive Haemophilus influenzae Disease-United States, 2009-2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000-2012.International journal of circumpolar health · 2016Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundInvasive infections from Haemophilus influenzae serotype a (Hia) have been reported with increasing frequency, especially among indigenous populations. However, there are limited population-based studies of clinical severity. We studied invasive Hia infections in Alaska to determine clinical characteristics, mortality and sequelae.
methodsWe defined an invasive Hia infection as the first detection of Hia from a usually sterile site in a child <10 years of age from Alaska. We identified cases using the Alaska Invasive Bacterial Diseases Surveillance System and reviewed medical charts up to 2 years after reported illness.
resultsWe identified invasive Hia infections in 36 children, 28 (78%) <1 year old, 34 (94%) living in an Alaskan village and 25 (69%) without documented underlying illness. Overlapping clinical presentations included meningitis in 15 children (42%); bacteremia and pneumonia in 10 children (28%); and bone, joint or soft tissue infections in 10 children (22%). In 4 other children, no source of invasive infection was identified. Intensive care was provided for 11 children (31%); 12 children (33%) required surgical intervention. One year after infection, 4 children (11%) had died from Hia, and 5 children (14%) had ongoing neurologic sequelae.
conclusionsInvasive Hia infections in Alaska occurred predominantly in Alaska Native infants in rural communities. Although one-third of children had preexisting conditions, most cases occurred without known comorbidity. Clinical syndromes were frequently severe. One year after infection, 1 in 4 children had either died or had neurologic sequelae. An effective vaccine would prevent significant morbidity and mortality in affected populations.
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