SynthesisPain2018
Surgical interventions for the treatment of painful neuroma: a comparative meta-analysis.
Synthesis in Pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy, Safety and Prognosis of Preventive Regenerative Peripheral Nerve Interface(RPNI) Reconstruction in Amputees: Study Protocol for a Cohort Study
A Proof-of-Concept Study to Define the Safety, Efficacy and Feasibility of Cryoanalgesia (Iovera°®) for the Treatment of Pain in Subjects With Morton's Neuroma
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.
- Sensory Abnormalities and Pain in the Donor Sites of Radial Forearm and Fibula Free Flaps-A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Targeted Muscle Reinnervation Improves Residual Limb Pain, Phantom Limb Pain, and Limb Function: A Prospective Study of 33 Major Limb Amputees.Clinical orthopaedics and related research · 2020Trial
- Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation.PNAS nexus · 2026Article
- Outcomes Following Regenerative Peripheral Nerve Interface Surgery and Associations With Preoperative Mental Health: A Retrospective Analysis of Upper-Extremity Neuromas.Journal of hand surgery global online · 2026Article
- From Amputation to Persistent Pain: A Review of Molecular and Cellular Processes in Phantom Limb Pain.International journal of molecular sciences · 2026Review
- Targeted Muscle Reinnervation to Lumbrical Muscles for Symptomatic Digital Stump Neuroma: Surgical Technique.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- Pedicled adipofascial flaps for treatment and prophylaxis of neurodesis and neuromas in continuity of the upper extremity: A case series of 22 patients.Journal of hand and microsurgery · 2025Article
- Lower Extremity Targeted Muscle Reinnervation for Mononeuropathy in Nonamputation Patients: Techniques and Tips.Plastic and reconstructive surgery. Global open · 2025Article
- Prevention of nerve growth and evoked pain with a nerve cap graft device.NPJ Regenerative medicine · 2025Article
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Ultrasound-guided platelet-rich plasma injection for traumatic painful neuroma of brachial plexus: a case report and literature review.Frontiers in neurology · 2025Article
- Surgical Outcomes of Spiral Vein Wrapping Flaps for Painful Neuromas: A Case Series Analysis.The American journal of case reports · 2024Article
- Improving outcomes in traumatic peripheral nerve injuries to the upper extremity.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Review
- Ten Myths in Nerve Surgery.Plastic and reconstructive surgery. Global open · 2024Article
- Outcomes of upper extremity sensory neuromas treated with excision and burial.Journal of hand and microsurgery · 2024Article
- Minimally invasive scar release by autologous adipose tissue transfer for post-traumatic neuropathic pain.Regenerative therapy · 2024Article
- Regenerative Peripheral Nerve Interface Surgery for the Management of Chronic Posttraumatic Neuropathic Pain.Seminars in plastic surgery · 2024Review
- Management of Neuropathic Pain with Neurectomy Combined with Dermal Sensory Regenerative Peripheral Nerve Interface (DS-RPNI).Seminars in plastic surgery · 2024Review
- Volume loss during muscle reinnervation surgery is correlated with reduced CMAP amplitude but not reduced force output in a rat hindlimb model.Frontiers in physiology · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A consensus on the optimal treatment of painful neuromas does not exist. Our objective was to identify available data and to examine the role of surgical technique on outcomes following surgical management of painful neuromas. In accordance with the PRISMA guidelines, we performed a comprehensive literature search to identify studies measuring the efficacy of the surgical treatment of painful neuromas in the extremities (excluding Morton's neuroma and compression neuropathies). Surgical treatments were categorized as excision-only, excision and transposition, excision and cap, excision and repair, or neurolysis and coverage. Data on the proportion of patients with a meaningful reduction in pain were pooled and a random-effects meta-analysis was performed. The effects of confounding, study quality, and publication bias were examined with stratified, meta-regression, and bias analysis. Fifty-four articles met the inclusion criteria, many with multiple treatment groups. Outcomes reporting varied significantly and few studies controlled for confounding. Overall, surgical treatment of neuroma pain was effective in 77% of patients [95% confidence interval: 73-81]. No significant differences were seen between surgical techniques. Among studies with a mean pain duration greater than 24 months, or median number of operations greater than 2 prior to definitive neuroma pain surgery, excision and transposition or neurolysis and coverage were significantly more likely than other operative techniques to result in a meaningful reduction in pain (P < 0.05). Standardization in the reporting of surgical techniques, outcomes, and confounding factors is needed in future studies to enable providers to make comparisons across disparate techniques in the surgical treatment of neuroma pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.