ArticleBehavioral neuroscience2017
The application of a rodent-based Morris water maze (MWM) protocol to an investigation of age-related differences in human spatial learning.
Article in Behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Virtual Morris Water Task: Procedures and Protocols for the Assessment of Spatial Navigation and Memory.Current protocols · 2026Article
- Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment.Frontiers in aging neuroscience · 2026Article
- Age differences in spatial navigation stem from a preference for familiar routes rather than impaired landmark-dependent strategies.Psychology and aging · 2025Article
- Higher levels of GluN1 splice cassettes, C2 and C2', in hippocampus of aged mice were associated with poor spatial reference memory.Brain research bulletin · 2025Article
- A cognitive-motor framework for spatial navigation in aging and early-stage Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Review
- Normal and slow learners: a new discriminative method based on the speed of spatial learning in aged mice.Frontiers in aging neuroscience · 2025Article
- Translatome and transcriptome profiling of neonatal mice hippocampus exposed to sevoflurane anesthesia.Heliyon · 2024Article
- Hippocampal contributions to novel spatial learning are both age-related and age-invariant.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hippocampal contributions to novel spatial learning are both age-related and age-invariant.bioRxiv : the preprint server for biology · 2023Article
- Assessing cognitive decline in the aging brain: lessons from rodent and human studies.npj aging · 2023Review
- GPR30 agonist G1 combined with hypothermia alleviates cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage in rats.Brain and behavior · 2023Article
- Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age.Neuron · 2023Review
- Virtual Reality for Spatial Navigation.Current topics in behavioral neurosciences · 2023Article
- Flurbiprofen axetil alleviates the effect of formalin-induced inflammatory pain on the cognitive function of rats with mild cognitive impairment through the AMPKα/NF-κB signaling pathway.Annals of translational medicine · 2022Article
- Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory.Experimental animals · 2022Review
- Effects of the Bark Resin Extract ofMolecules (Basel, Switzerland) · 2022Article
- Mitochondria-Related Ferroptosis Drives Cognitive Deficits in Neonatal Mice Following Sevoflurane Administration.Frontiers in medicine · 2022Article
- Impact of Spatial Orientation Ability on Air Traffic Conflict Detection in a Simulated Free Route Airspace Environment.Frontiers in human neuroscience · 2022Article
- Gut microbiota mediates cognitive impairment in young mice after multiple neonatal exposures to sevoflurane.Aging · 2021Article
- Older Adults Show Reduced Spatial Precision but Preserved Strategy-Use During Spatial Navigation Involving Body-Based Cues.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The current study applied a rodent-based Morris water maze (MWM) protocol to an investigation of search performance differences between young and older adult humans. To investigate whether similar age-related decline in search performance could be seen in humans based on the rodent-based protocol, we implemented a virtual MWM (vMWM) that has characteristics similar to those of the MWM used in previous studies of spatial learning in mice. Through the use of a proximity to platform measure, robust differences were found between healthy young and older adults in search performance. After dividing older adults into good and poor performers based on a median split of their corrected cumulative proximity values, the age effects in place learning were found to be largely related to search performance differences between the young and poor-performing older adults. When compared with the young, poor-performing older adults exhibited significantly higher proximity values in 83% of 24 place trials and overall in the probe trials that assessed spatial learning in the absence of the hidden platform. In contrast, good-performing older adults exhibited patterns of search performance that were comparable with that of the younger adults in most place and probe trials. Taken together, our findings suggest that the low search accuracy in poor-performing older adults stemmed from potential differences in strategy selection, differences in assumptions or expectations of task demands, as well as possible underlying functional and/or structural changes in the brain regions involved in vMWM search performance. (PsycINFO Database Record
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.