ArticleThe journal of nutrition, health & aging2017
Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ε4 and the Risk of Cognitive Decline and Incident Dementia.
Article in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults.GeroScience · 2024Trial
- Associations of plasma biomarkers of Alzheimer's disease pathology with modifiable risk factors and cognitive and functional outcomes: evidence from cross-sectional prediction and latent path analyses in the Bio-Hermes-001 cohort.Alzheimer's research & therapy · 2026Article
- Social and Cardiovascular Risk Factors as Predictors of the Progression from Mild Cognitive Impairment to Dementia in a Large EHR Database.medRxiv : the preprint server for health sciences · 2026Article
- An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.PLoS genetics · 2026Article
- Evaluate the Risk Factors of Mild Cognitive Impairment (MCI) in Patients with Type 2 Diabetes Mellitus (T2DM): A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Obesity, cardiometabolic health status, and brain health in community-dwelling older adults.Journal of Alzheimer's disease : JAD · 2026Article
- Twelve-year nationwide cohort study identifying risk factors for conversion from mild cognitive impairment to Alzheimer's disease.Scientific reports · 2025Article
- Investigating the impact of body weight changes and blood lipids on risk for mild cognitive impairment in Parkinson's disease: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Physical fitness and incident mild cognitive impairment: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- Article
- Sarcopenia is a predictor for Alzheimer's continuum and related clinical outcomes.Scientific reports · 2024Article
- Correlation between obesity and AlzheimerZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Sex-Specific Association of Body Mass Index with Hippocampal Subfield Volume and Cognitive Function in Non-Demented Chinese Older Adults.Brain sciences · 2024Article
- How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.Frontiers in aging · 2024Article
- Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Article
- Cognitive trajectories preluding the imminent onset of Alzheimer's disease dementia in individuals with normal cognition: results from the HELIAD cohort.Aging clinical and experimental research · 2023Article
- Gender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity.Alzheimer's research & therapy · 2022Article
- Long-term Weight Change and its Temporal Relation to Later-life Dementia in the Health and Retirement Study.The Journal of clinical endocrinology and metabolism · 2022Article
- ApoE4 Is Associated with Lower Body Mass, Particularly Fat Mass, in Older Women with Cognitive Impairment.Nutrients · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine the effect of late-life body mass index (BMI) and rapid weight loss on incident mild cognitive impairment (MCI) and Alzheimer's disease (AD).
designProspective longitudinal cohort study.
settingNational Alzheimer's Coordinating Center (NACC) Uniform Data Set, including 34 past and current National Institute on Aging-funded AD Centers across the United States.
participants6940 older adults (n=5061 normal cognition [NC]; n=1879 MCI). MEASUREMENTS: BMI (kg/m2) and modified Framingham Stroke Risk Profile (FSRP) score (sex, age, systolic blood pressure, anti-hypertension medication, diabetes mellitus, cigarette smoking, prevalent cardiovascular disease, atrial fibrillation) were assessed at baseline. Cognition and weight were assessed annually.
resultsMultivariable binary logistic regression, adjusting for age, sex, race, education, length of follow-up, and modified FSRP related late-life BMI to risk of diagnostic conversion from NC to MCI or AD and from MCI to AD. Secondary analyses related late-life BMI to diagnostic conversion in the presence of rapid weight loss (>5% decrease in 12 months) and apolipoprotein E (APOE) ε4. During a mean 3.8-year follow-up period, 12% of NC participants converted to MCI or AD and 49% of MCI participants converted to AD. Higher baseline BMI was associated with a reduced probability of diagnostic conversion, such that for each one-unit increase in baseline BMI there was a reduction in diagnostic conversion for both NC (OR=0.977, 95%CI 0.958-0.996, p=0.015) and MCI participants (OR=0.962, 95%CI 0.942-0.983, p<0.001). The protective effect of higher baseline BMI did not persist in the setting of rapid weight loss but did persist when adjusting for APOE ε4.
conclusionsHigher late-life BMI is associated with a lower risk of incident MCI and AD but is not protective in the presence of rapid weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.