Evidence map›Paper›PMID 29188875›Full record

Trial reportThe journal of nutrition, health & aging2017

Intake of a Protein-Enriched Milk and Effects on Muscle Mass and Strength. A 12-Week Randomized Placebo Controlled Trial among Community-Dwelling Older Adults.

I Ottestad, A T Løvstad, G O Gjevestad, H Hamarsland, J Šaltytė Benth, L F Andersen, A Bye, A S Biong, K Retterstøl, P O Iversen and 3 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02218333 (Effect of Milk Proteins on Body Composition, Muscle Strength, Inflammation and Bone Health in Elderly Subjects), which is not on this map. Cited by 24 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02218333 nacompletednot on this map

Effect of Milk Proteins on Body Composition, Muscle Strength, Inflammation and Bone Health in Elderly Subjects

TypeinterventionalSponsorUniversity of OsloRan2014 to 2015Enrolled50ConditionsHealthyArmsMilk, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

I OttestadInger Ottestad, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317 Oslo, Norway. Tel: + 47-228540206, Inger.Ottestad@medisin.uio.no.
A T Løvstad
G O Gjevestad
H Hamarsland
J Šaltytė Benth
L F Andersen
A Bye
A S Biong
K Retterstøl
P O Iversen
T Raastad
S M Ulven
K B Holven

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effect of 20 g protein with breakfast and evening meal on muscle mass, muscle strength and functional performance in older adults.

designA double-blinded randomized controlled study.

settingOslo and Akershus University College of Applied Sciences, Norway.

participantsHealthy community-dwelling men and women (≥ 70 years) with reduced physical strength and/or performance.

interventionSubjects were randomly assigned to receive either protein-enriched milk (2 x 0.4 L/d; protein group) or an isocaloric carbohydrate drink (2 x 0.4 L/d; control group) with breakfast and evening meal for 12 weeks. MEASUREMENTS: The primary endpoints were muscle mass measured by dual X-ray absorptiometry, and tests of muscle strength (one repetition maximum test of chest press and leg press) and functional performance (handgrip strength, stair calimb and repeated chair rise).

resultsIn total, 438 subjects were screened, 50 subjects were randomized and 36 completed the study. Chest press improved significantly in the protein (1.3 kg (0.1-2.5), p=0.03) and the control group (1.5 kg (0.0-3.0), p=0.048), but with no difference between the groups (p=0.85). No significant change in leg press (p=0.93) or muscle mass (p=0.54) were observed between the protein and the control group. Nor did we observe any significant differences in the functional performance tests (p>0.05 for all tests) between the groups.

conclusionIncreased protein intake (2 x 20 g/d) did not significantly improve muscle mass, muscle strength or functional performance in healthy older weight stable adults. Whether intake of > 20 g protein to each meal is necessary for preservation of muscle mass and strength in older adults should be further investigated in a larger study. This underscores the need for well-designed studies that can differentiate between the effect of protein intake and increased energy. This trial was registered at Clinicaltrials.gov (ID no. NCT02218333).

Indexed as

AgedAged, 80 and overAnimalsDouble-Blind MethodFemaleHumansIndependent LivingMaleMilk ProteinsMuscle, SkeletalMuscle StrengthMilk Proteinsmilkmuscle massmuscle strengtholder adultsProtein

Identifiers

PMID29188875
PMCPMC12879784

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.